PRMT1 loss sensitizes cells to PRMT5 inhibition

PRMT5 is an arginine methyltransferase that accounts for the vast majority of the symmetric methylation in cells. PRMT5 exerts its function when complexed with MEP50/WDR77. This activity is often elevated in cancer cells and correlates with poor prognosis, making PRMT5 a therapeutic target. To inves...

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Detalles Bibliográficos
Autores principales: Gao, Guozhen, Zhang, Liang, Villarreal, Oscar D, He, Wei, Su, Dan, Bedford, Ella, Moh, Phoebe, Shen, Jianjun, Shi, Xiaobing, Bedford, Mark T, Xu, Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547413/
https://www.ncbi.nlm.nih.gov/pubmed/30916320
http://dx.doi.org/10.1093/nar/gkz200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547413/
https://www.ncbi.nlm.nih.gov/pubmed/30916320
http://dx.doi.org/10.1093/nar/gkz200

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