Cargando…

PRMT1 loss sensitizes cells to PRMT5 inhibition

PRMT5 is an arginine methyltransferase that accounts for the vast majority of the symmetric methylation in cells. PRMT5 exerts its function when complexed with MEP50/WDR77. This activity is often elevated in cancer cells and correlates with poor prognosis, making PRMT5 a therapeutic target. To inves...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gao, Guozhen, Zhang, Liang, Villarreal, Oscar D, He, Wei, Su, Dan, Bedford, Ella, Moh, Phoebe, Shen, Jianjun, Shi, Xiaobing, Bedford, Mark T, Xu, Han
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547413/ https://www.ncbi.nlm.nih.gov/pubmed/30916320 http://dx.doi.org/10.1093/nar/gkz200

Ejemplares similares

PRMT5 regulates IRES-dependent translation via methylation of hnRNP A1
por: Gao, Guozhen, et al.
Publicado: (2017)

A gain-of-function mouse model identifies PRMT6 as a NF-κB coactivator
por: Di Lorenzo, Alessandra, et al.
Publicado: (2014)

The expression of myogenic microRNAs indirectly requires protein arginine methyltransferase (Prmt)5 but directly requires Prmt4
por: Mallappa, Chandrashekara, et al.
Publicado: (2011)

Klf4 methylated by Prmt1 restrains the commitment of primitive endoderm
por: Zuo, Zhen-yu, et al.
Publicado: (2022)

A feedback regulatory loop between methyltransferase PRMT1 and orphan receptor TR3
por: Lei, Na-zi, et al.
Publicado: (2009)

Bromodomain protein 7 interacts with PRMT5 and PRC2, and is involved in transcriptional repression of their target genes
por: Tae, Sookil, et al.
Publicado: (2011)

The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer
por: Rengasamy, Madhumitha, et al.
Publicado: (2017)

PRMT5-mediated histone arginine methylation antagonizes transcriptional repression by polycomb complex PRC2
por: Liu, Fan, et al.
Publicado: (2020)

The arginine methyltransferase Prmt1 coordinates the germline arginine methylome essential for spermatogonial homeostasis and male fertility
por: Azhar, Muhammad, et al.
Publicado: (2023)

Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor
por: Neault, Mathieu, et al.
Publicado: (2012)

The arginine methyltransferase PRMT6 regulates cell proliferation and senescence through transcriptional repression of tumor suppressor genes
por: Stein, Claudia, et al.
Publicado: (2012)

p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6
por: Phalke, Sameer, et al.
Publicado: (2012)

Promoter–enhancer looping at the PPARγ2 locus during adipogenic differentiation requires the Prmt5 methyltransferase
por: LeBlanc, Scott E., et al.
Publicado: (2016)

PRMT5-mediated histone H4 arginine-3 symmetrical dimethylation marks chromatin at G + C-rich regions of the mouse genome
por: Girardot, Michael, et al.
Publicado: (2014)

A feedback loop comprising PRMT7 and miR-24-2 interplays with Oct4, Nanog, Klf4 and c-Myc to regulate stemness
por: Lee, Sung-Hun, et al.
Publicado: (2016)

PHD finger protein 1 (PHF1) is a novel reader for histone H4R3 symmetric dimethylation and coordinates with PRMT5–WDR77/CRL4B complex to promote tumorigenesis
por: Liu, Ruiqiong, et al.
Publicado: (2018)

Binding of 14-3-3 reader proteins to phosphorylated DNMT1 facilitates aberrant DNA methylation and gene expression
por: Estève, Pierre-Olivier, et al.
Publicado: (2016)

Methylation-directed acetylation of histone H3 regulates developmental sensitivity to histone deacetylase inhibition
por: Huang, Li-Yao, et al.
Publicado: (2021)

Estrogen-induced transcription at individual alleles is independent of receptor level and active conformation but can be modulated by coactivators activity
por: Stossi, Fabio, et al.
Publicado: (2020)

What is a supercoiling-sensitive gene? Insights from topoisomerase I inhibition in the Gram-negative bacterium Dickeya dadantii
por: Pineau, Maïwenn, et al.
Publicado: (2022)

eIF3j inhibits translation of a subset of circular RNAs in eukaryotic cells
por: Song, Zhenxing, et al.
Publicado: (2022)

Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis
por: Lee, Ying-Ying, et al.
Publicado: (2018)

KLF4 inhibits early neural differentiation of ESCs by coordinating specific 3D chromatin structure
por: Bi, Jinfang, et al.
Publicado: (2022)

Histone benzoylation serves as an epigenetic mark for DPF and YEATS family proteins
por: Ren, Xiangle, et al.
Publicado: (2020)

Loci specific epigenetic drug sensitivity
por: Zhang, Thanutra, et al.
Publicado: (2020)

DNA deletion as a mechanism for developmentally programmed centromere loss
por: Lhuillier-Akakpo, Maoussi, et al.
Publicado: (2016)

Two-step interrogation then recognition of DNA binding site by Integration Host Factor: an architectural DNA-bending protein
por: Velmurugu, Yogambigai, et al.
Publicado: (2018)

Autoregulation of topoisomerase I expression by supercoiling sensitive transcription
por: Ahmed, Wareed, et al.
Publicado: (2016)

Demonstration of all-or-none loss of imprinting in mRNA expression in single cells
por: Diplas, Andreas I., et al.
Publicado: (2009)

Genome-wide profiling of nucleosome sensitivity and chromatin accessibility in Drosophila melanogaster
por: Chereji, Răzvan V., et al.
Publicado: (2016)

Accumulation and loss of asymmetric non-CpG methylation during male germ-cell development
por: Ichiyanagi, Tomoko, et al.
Publicado: (2013)

Acute depletion of CTCF directly affects MYC regulation through loss of enhancer–promoter looping
por: Hyle, Judith, et al.
Publicado: (2019)

An internal ribosomal entry site mediates redox-sensitive translation of Nrf2
por: Li, Wenge, et al.
Publicado: (2010)

HiCDB: a sensitive and robust method for detecting contact domain boundaries
por: Chen, Fengling, et al.
Publicado: (2018)

Loss of EZH2 results in precocious mammary gland development and activation of STAT5-dependent genes
por: Yoo, Kyung Hyun, et al.
Publicado: (2015)

DOT1L promotes progenitor proliferation and primes neuronal layer identity in the developing cerebral cortex
por: Franz, Henriette, et al.
Publicado: (2019)

Stra13/DEC1 and DEC2 inhibit sterol regulatory element binding protein-1c in a hypoxia-inducible factor-dependent mechanism
por: Choi, Su Mi, et al.
Publicado: (2008)

Loss of imprinting mutations define both distinct and overlapping roles for misexpression of IGF2 and of H19 lncRNA
por: Park, Ki-Sun, et al.
Publicado: (2017)

Loss of histone methyltransferase SETD1B in oogenesis results in the redistribution of genomic histone 3 lysine 4 trimethylation
por: Hanna, Courtney W, et al.
Publicado: (2022)

Induction of senescence upon loss of the Ash2l core subunit of H3K4 methyltransferase complexes
por: Bochyńska, Agnieszka, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_mslob2f7p4af5vdhekmsav8b83