The m(6)A-suppressed P2RX6 activation promotes renal cancer cells migration and invasion through ATP-induced Ca(2+) influx modulating ERK1/2 phosphorylation and MMP9 signaling pathway

BACKGROUND: Previous study demonstrated that extracellular ATP could promote cell migration and invasion in multiple human cancers. Till now, the pro-invasive mechanisms of ATP and P2RX6, a preferred receptor for ATP, are still poorly studied in RCC. METHODS: Bioinformatics analysis was performed to...

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Detalles Bibliográficos
Autores principales: Gong, Dongkui, Zhang, Jin, Chen, Yonghui, Xu, Yunfei, Ma, Junjie, Hu, Guanghui, Huang, Yiran, Zheng, Junhua, Zhai, Wei, Xue, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547495/
https://www.ncbi.nlm.nih.gov/pubmed/31159832
http://dx.doi.org/10.1186/s13046-019-1223-y

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