Synthesis, Derivatization, and Structural Analysis of Phosphorylated Mono-, Di-, and Trifluorinated d-Gluco-heptuloses by Glucokinase: Tunable Phosphoglucomutase Inhibition

[Image: see text] Glucokinase phosphorylated a series of C-1 fluorinated α-d-gluco-heptuloses. These phosphorylated products were discovered to be inhibitors of α-phosphomannomutase/phosphoglucomutase (αPMM/PGM) and β-phosphoglucomutase (βPGM). Inhibition potency with both mutases inversely correlat...

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Detalles Bibliográficos
Autores principales: Zhu, Jian-She, Stiers, Kyle M., Winter, Sherany M., Garcia, Anthony D., Versini, Antoine F., Beamer, Lesa J., Jakeman, David L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547622/
https://www.ncbi.nlm.nih.gov/pubmed/31179410
http://dx.doi.org/10.1021/acsomega.9b00008

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