Beyond Traditional Structure-Based Drug Design: The Role of Iron Complexation, Strain, and Water in the Binding of Inhibitors for Hypoxia-Inducible Factor Prolyl Hydroxylase 2

[Image: see text] A combination of structure-based drug design and medicinal chemistry efforts led us from benzimidazole-2-carboxamide with modestly active hypoxia-inducible factor prolyl hydroxylase 2 inhibition to certain benzimidazole-2-pyrazole carboxylic acids that were more potent as well as o...

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Detalles Bibliográficos
Autores principales: Bembenek, Scott D., Venkatesan, Hariharan, Peltier, Hillary M., Rosen, Mark D., Barrett, Terrance D., Kanelakis, Kimon C., Palomino, Heather L., Brondstetter, Theresa I., Mirzadegan, Taraneh, Rabinowitz, Michael H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547624/
https://www.ncbi.nlm.nih.gov/pubmed/31179408
http://dx.doi.org/10.1021/acsomega.9b00199

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