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Radiation-dose-dependent functional synergisms between ATM, ATR and DNA-PKcs in checkpoint control and resection in G(2)-phase

Using data generated with cells exposed to ionizing-radiation (IR) in G(2)-phase of the cell cycle, we describe dose-dependent interactions between ATM, ATR and DNA-PKcs revealing unknown mechanistic underpinnings for two key facets of the DNA damage response: DSB end-resection and G(2)-checkpoint a...

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Detalles Bibliográficos
Autores principales:	Mladenov, Emil, Fan, Xiaoxiang, Dueva, Rositsa, Soni, Aashish, Iliakis, George
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547644/ https://www.ncbi.nlm.nih.gov/pubmed/31164689 http://dx.doi.org/10.1038/s41598-019-44771-6

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