Activated Peyer′s patch B cells sample antigen directly from M cells in the subepithelial dome

The germinal center (GC) reaction in Peyer′s patches (PP) requires continuous access to antigens, but how this is achieved is not known. Here we show that activated antigen-specific CCR6(+)CCR1(+)GL7(−) B cells make close contact with M cells in the subepithelial dome (SED). Using in situ photoactiv...

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Detalles Bibliográficos
Autores principales: Komban, Rathan Joy, Strömberg, Anneli, Biram, Adi, Cervin, Jakob, Lebrero-Fernández, Cristina, Mabbott, Neil, Yrlid, Ulf, Shulman, Ziv, Bemark, Mats, Lycke, Nils
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547658/
https://www.ncbi.nlm.nih.gov/pubmed/31160559
http://dx.doi.org/10.1038/s41467-019-10144-w

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