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Detection of DNA base modifications by deep recurrent neural network on Oxford Nanopore sequencing data

DNA base modifications, such as C5-methylcytosine (5mC) and N6-methyldeoxyadenosine (6mA), are important types of epigenetic regulations. Short-read bisulfite sequencing and long-read PacBio sequencing have inherent limitations to detect DNA modifications. Here, using raw electric signals of Oxford...

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Detalles Bibliográficos
Autores principales:	Liu, Qian, Fang, Li, Yu, Guoliang, Wang, Depeng, Xiao, Chuan-Le, Wang, Kai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547721/ https://www.ncbi.nlm.nih.gov/pubmed/31164644 http://dx.doi.org/10.1038/s41467-019-10168-2

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