Functional characterisation of a novel class of in-frame insertion variants of KRAS and HRAS

Mutations in the RAS genes are identified in a variety of clinical settings, ranging from somatic mutations in oncology to germline mutations in developmental disorders, also known as ‘RASopathies’, and vascular malformations/overgrowth syndromes. Generally single amino acid substitutions are identi...

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Detalles Bibliográficos
Autores principales: Eijkelenboom, Astrid, van Schaik, Frederik M. A., van Es, Robert M., Ten Broek, Roel W., Rinne, Tuula, van der Vleuten, Carine, Flucke, Uta, Ligtenberg, Marjolijn J. L., Rehmann, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547725/
https://www.ncbi.nlm.nih.gov/pubmed/31160609
http://dx.doi.org/10.1038/s41598-019-44584-7

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