Integrative transcriptomic analysis suggests new autoregulatory splicing events coupled with nonsense-mediated mRNA decay

Nonsense-mediated decay (NMD) is a eukaryotic mRNA surveillance system that selectively degrades transcripts with premature termination codons (PTC). Many RNA-binding proteins (RBP) regulate their expression levels by a negative feedback loop, in which RBP binds its own pre-mRNA and causes alternati...

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Detalles Bibliográficos
Autores principales: Pervouchine, Dmitri, Popov, Yaroslav, Berry, Andy, Borsari, Beatrice, Frankish, Adam, Guigó, Roderic
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547761/
https://www.ncbi.nlm.nih.gov/pubmed/30916337
http://dx.doi.org/10.1093/nar/gkz193

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