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Alcohol consumption is associated with the risk of developing colorectal neoplasia: Propensity score matching analysis
Although alcohol intake is known to be associated with the development of colorectal cancer, the effect of alcohol consumption on the development of colorectal neoplasm (CRN) is unclear. We performed a retrospective cohort analysis with 1 to 1 propensity score matching in a single center of Korea. A...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547846/ https://www.ncbi.nlm.nih.gov/pubmed/31164696 http://dx.doi.org/10.1038/s41598-019-44719-w |
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author | Yang, Young Joo Bang, Chang Seok Choi, Jae Ho Lee, Jae Jun Shin, Suk Pyo Suk, Ki Tae Baik, Gwang Ho Kim, Dong Joon |
author_facet | Yang, Young Joo Bang, Chang Seok Choi, Jae Ho Lee, Jae Jun Shin, Suk Pyo Suk, Ki Tae Baik, Gwang Ho Kim, Dong Joon |
author_sort | Yang, Young Joo |
collection | PubMed |
description | Although alcohol intake is known to be associated with the development of colorectal cancer, the effect of alcohol consumption on the development of colorectal neoplasm (CRN) is unclear. We performed a retrospective cohort analysis with 1 to 1 propensity score matching in a single center of Korea. Among 1,448 patients who underwent index and surveillance colonoscopy, 210 matched pairs were analyzed. The 5-year cumulative occurrence of overall CRN after index colonoscopy was higher in the significant alcohol consumption group (defined as alcohol consumption more than 30 g/day in men and 20 g/day in women) (vs. without significant alcohol consumption group) (40% vs. 27.6%, p = 0.004). Significant alcohol consumption increased the development of overall CRN (adjusted hazard ratio [aHR]: 1.86, 95% confidence interval [CI]: 1.28–2.70, p = 0.001) at surveillance colonoscopy. However, this effect was not valid on the development of advanced CRN. In subgroup analysis considering the risk classification of index colonoscopy, significant alcohol consumption increased the overall CRN development at surveillance colonoscopy in the normal group (patients with no detected adenoma in the index colonoscopy) (aHR: 1.90, 95% CI: 1.16–3.13, p = 0.01). Alcohol consumption habits should be considered in optimizing time intervals of surveillance colonoscopy. |
format | Online Article Text |
id | pubmed-6547846 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-65478462019-06-10 Alcohol consumption is associated with the risk of developing colorectal neoplasia: Propensity score matching analysis Yang, Young Joo Bang, Chang Seok Choi, Jae Ho Lee, Jae Jun Shin, Suk Pyo Suk, Ki Tae Baik, Gwang Ho Kim, Dong Joon Sci Rep Article Although alcohol intake is known to be associated with the development of colorectal cancer, the effect of alcohol consumption on the development of colorectal neoplasm (CRN) is unclear. We performed a retrospective cohort analysis with 1 to 1 propensity score matching in a single center of Korea. Among 1,448 patients who underwent index and surveillance colonoscopy, 210 matched pairs were analyzed. The 5-year cumulative occurrence of overall CRN after index colonoscopy was higher in the significant alcohol consumption group (defined as alcohol consumption more than 30 g/day in men and 20 g/day in women) (vs. without significant alcohol consumption group) (40% vs. 27.6%, p = 0.004). Significant alcohol consumption increased the development of overall CRN (adjusted hazard ratio [aHR]: 1.86, 95% confidence interval [CI]: 1.28–2.70, p = 0.001) at surveillance colonoscopy. However, this effect was not valid on the development of advanced CRN. In subgroup analysis considering the risk classification of index colonoscopy, significant alcohol consumption increased the overall CRN development at surveillance colonoscopy in the normal group (patients with no detected adenoma in the index colonoscopy) (aHR: 1.90, 95% CI: 1.16–3.13, p = 0.01). Alcohol consumption habits should be considered in optimizing time intervals of surveillance colonoscopy. Nature Publishing Group UK 2019-06-04 /pmc/articles/PMC6547846/ /pubmed/31164696 http://dx.doi.org/10.1038/s41598-019-44719-w Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Yang, Young Joo Bang, Chang Seok Choi, Jae Ho Lee, Jae Jun Shin, Suk Pyo Suk, Ki Tae Baik, Gwang Ho Kim, Dong Joon Alcohol consumption is associated with the risk of developing colorectal neoplasia: Propensity score matching analysis |
title | Alcohol consumption is associated with the risk of developing colorectal neoplasia: Propensity score matching analysis |
title_full | Alcohol consumption is associated with the risk of developing colorectal neoplasia: Propensity score matching analysis |
title_fullStr | Alcohol consumption is associated with the risk of developing colorectal neoplasia: Propensity score matching analysis |
title_full_unstemmed | Alcohol consumption is associated with the risk of developing colorectal neoplasia: Propensity score matching analysis |
title_short | Alcohol consumption is associated with the risk of developing colorectal neoplasia: Propensity score matching analysis |
title_sort | alcohol consumption is associated with the risk of developing colorectal neoplasia: propensity score matching analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547846/ https://www.ncbi.nlm.nih.gov/pubmed/31164696 http://dx.doi.org/10.1038/s41598-019-44719-w |
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