Lamin B1 loss promotes lung cancer development and metastasis by epigenetic derepression of RET

Although abnormal nuclear structure is an important criterion for cancer diagnostics, remarkably little is known about its relationship to tumor development. Here we report that loss of lamin B1, a determinant of nuclear architecture, plays a key role in lung cancer. We found that lamin B1 levels we...

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Detalles Bibliográficos
Autores principales: Jia, Yanhan, Vong, Joaquim Si-Long, Asafova, Alina, Garvalov, Boyan K., Caputo, Luca, Cordero, Julio, Singh, Anshu, Boettger, Thomas, Günther, Stefan, Fink, Ludger, Acker, Till, Barreto, Guillermo, Seeger, Werner, Braun, Thomas, Savai, Rajkumar, Dobreva, Gergana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547854/
https://www.ncbi.nlm.nih.gov/pubmed/31015297
http://dx.doi.org/10.1084/jem.20181394

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