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Phosphorylation-dependent Regnase-1 release from endoplasmic reticulum is critical in IL-17 response

Regnase-1 (also known as Zc3h12a or MCPIP-1) is an endoribonuclease involved in mRNA degradation of inflammation-associated genes. Regnase-1 is inactivated in response to external stimuli through post-translational modifications including phosphorylation, yet the precise role of phosphorylation rema...

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Detalles Bibliográficos
Autores principales: Tanaka, Hiroki, Arima, Yasunobu, Kamimura, Daisuke, Tanaka, Yuki, Takahashi, Noriyuki, Uehata, Takuya, Maeda, Kazuhiko, Satoh, Takashi, Murakami, Masaaki, Akira, Shizuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547859/
https://www.ncbi.nlm.nih.gov/pubmed/31072819
http://dx.doi.org/10.1084/jem.20181078