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CDCA5, Transcribed by E2F1, Promotes Oncogenesis by Enhancing Cell Proliferation and Inhibiting Apoptosis via the AKT Pathway in Hepatocellular Carcinoma

Cell division cycle associated 5 (CDCA5) is an important element for the interaction between cohesin and chromatin in interphase. It is abnormally expressed in many types of cancer and works as an indicator of poor prognosis, but little is known about its activity in hepatocellular carcinoma (HCC)....

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Autores principales: Chen, Hao, Chen, Jun, Zhao, Long, Song, Wenfeng, Xuan, Zefeng, Chen, Jian, Li, Zequn, Song, Guangyuan, Hong, Liangjie, Song, Penghong, Zheng, Shusen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547986/
https://www.ncbi.nlm.nih.gov/pubmed/31205541
http://dx.doi.org/10.7150/jca.28809
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author Chen, Hao
Chen, Jun
Zhao, Long
Song, Wenfeng
Xuan, Zefeng
Chen, Jian
Li, Zequn
Song, Guangyuan
Hong, Liangjie
Song, Penghong
Zheng, Shusen
author_facet Chen, Hao
Chen, Jun
Zhao, Long
Song, Wenfeng
Xuan, Zefeng
Chen, Jian
Li, Zequn
Song, Guangyuan
Hong, Liangjie
Song, Penghong
Zheng, Shusen
author_sort Chen, Hao
collection PubMed
description Cell division cycle associated 5 (CDCA5) is an important element for the interaction between cohesin and chromatin in interphase. It is abnormally expressed in many types of cancer and works as an indicator of poor prognosis, but little is known about its activity in hepatocellular carcinoma (HCC). In the present study, we found that the expression of CDCA5 was upregulated in HCC tissues compared to paracancerous tissues and had a negative correlation with patient survival. Cell proliferation and tumorigenesis were inhibited and cell apoptosis was induced with the knockdown of CDCA5, suggesting an oncogenic role of CDCA5 in liver cancer. Luciferase reporter assay and chromatin immunoprecipitation showed that CDCA5 was transcribed by E2F1. Furthermore, we confirmed that CDCA5 interrupted cell behavior via the AKT pathway. These findings demonstrated that CDCA5 plays an important role in HCC progression.
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spelling pubmed-65479862019-06-14 CDCA5, Transcribed by E2F1, Promotes Oncogenesis by Enhancing Cell Proliferation and Inhibiting Apoptosis via the AKT Pathway in Hepatocellular Carcinoma Chen, Hao Chen, Jun Zhao, Long Song, Wenfeng Xuan, Zefeng Chen, Jian Li, Zequn Song, Guangyuan Hong, Liangjie Song, Penghong Zheng, Shusen J Cancer Research Paper Cell division cycle associated 5 (CDCA5) is an important element for the interaction between cohesin and chromatin in interphase. It is abnormally expressed in many types of cancer and works as an indicator of poor prognosis, but little is known about its activity in hepatocellular carcinoma (HCC). In the present study, we found that the expression of CDCA5 was upregulated in HCC tissues compared to paracancerous tissues and had a negative correlation with patient survival. Cell proliferation and tumorigenesis were inhibited and cell apoptosis was induced with the knockdown of CDCA5, suggesting an oncogenic role of CDCA5 in liver cancer. Luciferase reporter assay and chromatin immunoprecipitation showed that CDCA5 was transcribed by E2F1. Furthermore, we confirmed that CDCA5 interrupted cell behavior via the AKT pathway. These findings demonstrated that CDCA5 plays an important role in HCC progression. Ivyspring International Publisher 2019-04-21 /pmc/articles/PMC6547986/ /pubmed/31205541 http://dx.doi.org/10.7150/jca.28809 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Chen, Hao
Chen, Jun
Zhao, Long
Song, Wenfeng
Xuan, Zefeng
Chen, Jian
Li, Zequn
Song, Guangyuan
Hong, Liangjie
Song, Penghong
Zheng, Shusen
CDCA5, Transcribed by E2F1, Promotes Oncogenesis by Enhancing Cell Proliferation and Inhibiting Apoptosis via the AKT Pathway in Hepatocellular Carcinoma
title CDCA5, Transcribed by E2F1, Promotes Oncogenesis by Enhancing Cell Proliferation and Inhibiting Apoptosis via the AKT Pathway in Hepatocellular Carcinoma
title_full CDCA5, Transcribed by E2F1, Promotes Oncogenesis by Enhancing Cell Proliferation and Inhibiting Apoptosis via the AKT Pathway in Hepatocellular Carcinoma
title_fullStr CDCA5, Transcribed by E2F1, Promotes Oncogenesis by Enhancing Cell Proliferation and Inhibiting Apoptosis via the AKT Pathway in Hepatocellular Carcinoma
title_full_unstemmed CDCA5, Transcribed by E2F1, Promotes Oncogenesis by Enhancing Cell Proliferation and Inhibiting Apoptosis via the AKT Pathway in Hepatocellular Carcinoma
title_short CDCA5, Transcribed by E2F1, Promotes Oncogenesis by Enhancing Cell Proliferation and Inhibiting Apoptosis via the AKT Pathway in Hepatocellular Carcinoma
title_sort cdca5, transcribed by e2f1, promotes oncogenesis by enhancing cell proliferation and inhibiting apoptosis via the akt pathway in hepatocellular carcinoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547986/
https://www.ncbi.nlm.nih.gov/pubmed/31205541
http://dx.doi.org/10.7150/jca.28809
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