Cargando…

P16 Methylation Leads to Paclitaxel Resistance of Advanced Non-Small Cell Lung Cancer

Paclitaxel-based chemotherapy is widely used as the first-line treatment for non-small cell lung cancer (NSCLC). However, only 20%-40% of patients have shown sensitivity to paclitaxel. This study aimed to investigate whether P16 methylation could be used to predict paclitaxel chemosensitivity of NSC...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Zhaojun, Lin, Hongmei, Gan, Ying, Cui, Chenghua, Zhang, Baozhen, Gu, Liankun, Zhou, Jing, Zhu, Guangying, Deng, Dajun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547999/ https://www.ncbi.nlm.nih.gov/pubmed/31205528 http://dx.doi.org/10.7150/jca.26482

Ejemplares similares

P16-specific DNA methylation by engineered zinc finger methyltransferase inactivates gene transcription and promotes cancer metastasis
por: Cui, Chenghua, et al.
Publicado: (2015)

Significant impact of amount of PCR input templates on various PCR-based DNA methylation analysis and countermeasure
por: Liu, Zhaojun, et al.
Publicado: (2016)

CDKN2A Deletion Leading to Hematogenous Metastasis of Human Gastric Carcinoma
por: Qiao, Juanli, et al.
Publicado: (2021)

Chidamide increases the sensitivity of Non-small Cell Lung Cancer to Crizotinib by decreasing c-MET mRNA methylation
por: Ding, Nan, et al.
Publicado: (2020)

P16 methylation increases the sensitivity of cancer cells to the CDK4/6 inhibitor palbociclib
por: Li, Paiyun, et al.
Publicado: (2019)

Polycomb CBX7 Directly Controls Trimethylation of Histone H3 at Lysine 9 at the p16 Locus
por: Li, Qiang, et al.
Publicado: (2010)

P16 Methylation as an Early Predictor for Cancer Development From Oral Epithelial Dysplasia: A Double-blind Multicentre Prospective Study
por: Liu, Hongwei, et al.
Publicado: (2015)

Kaiso phosphorylation at threonine 606 leads to its accumulation in the cytoplasm, reducing its transcriptional repression of the tumour suppressor CDH1
por: Tian, Wei, et al.
Publicado: (2022)

C-terminal in Sp1-like artificial zinc-finger proteins plays crucial roles in determining their DNA binding affinity
por: Zhang, Baozhen, et al.
Publicado: (2013)

Detection of somatic copy number deletion of the CDKN2A gene by quantitative multiplex PCR for clinical practice
por: Tian, Yuan, et al.
Publicado: (2022)

Characterization of human gastric carcinoma-related methylation of 9 miR CpG islands and repression of their expressions in vitro and in vivo
por: Du, Yantao, et al.
Publicado: (2012)

SRF promotes gastric cancer metastasis through stromal fibroblasts in an SDF1-CXCR4-dependent manner
por: Qiao, Juanli, et al.
Publicado: (2016)

A similar effect of P16 hydroxymethylation and true-methylation on the prediction of malignant transformation of oral epithelial dysplasia: observation from a prospective study
por: Liu, Hongwei, et al.
Publicado: (2018)

miR663a-TTC22V1 axis inhibits colon cancer metastasis
por: Tian, Wei, et al.
Publicado: (2019)

P14AS upregulates gene expression in the CDKN2A/2B locus through competitive binding to PcG protein CBX7
por: Li, Zhuoqi, et al.
Publicado: (2022)

Corrigendum: P14AS upregulates gene expression in the CDKN2A/2B locus through competitive binding to PcG protein CBX7
por: Li, Zhuoqi, et al.
Publicado: (2022)

Methylation status of individual CpG sites within Alu elements in the human genome and Alu hypomethylation in gastric carcinomas
por: Xiang, Shengyan, et al.
Publicado: (2010)

Phase 3 Randomized Low-Dose Paclitaxel Chemoradiotherapy Study for Locally Advanced Non-Small Cell Lung Cancer
por: Lin, Hongmei, et al.
Publicado: (2016)

Combination of Paclitaxel and PXR Antagonist SPA70 Reverses Paclitaxel-Resistant Non-Small Cell Lung Cancer
por: Niu, Xiaxia, et al.
Publicado: (2022)

Bone Marrow-Derived Cells May Not Be the Original Cells for Carcinogen-Induced Mouse Gastrointestinal Carcinomas
por: Yang, Chen, et al.
Publicado: (2013)

Critical evaluation of Cbx7 downregulation in primary colon carcinomas and its clinical significance in Chinese patients
por: Zheng, Xiang, et al.
Publicado: (2015)

Characterization of novel LncRNA P14AS as a protector of ANRIL through AUF1 binding in human cells
por: Ma, Wanru, et al.
Publicado: (2020)

Pseudogenes and the associated ceRNA network as potential prognostic biomarkers for colorectal cancer
por: Li, Zhuoqi, et al.
Publicado: (2022)

Prevalence of A2143G mutation of H. pylori-23S rRNA in Chinese subjects with and without clarithromycin use history
por: Liu, Zhuoqi, et al.
Publicado: (2008)

MALAT1–miR663a negative feedback loop in colon cancer cell functions through direct miRNA–lncRNA binding
por: Tian, Wei, et al.
Publicado: (2018)

Cost-effectiveness of paclitaxel plus cisplatin in advanced non-small-cell lung cancer
por: Earle, C C, et al.
Publicado: (1999)

Evaluation of the Impact of Intratumoral Heterogeneity of Esophageal Cancer on Pathological Diagnosis and P16 Methylation and the Representativity of Endoscopic Biopsy
por: Qin, Yu, et al.
Publicado: (2021)

Gemcitabine with either paclitaxel or vinorelbine vs paclitaxel or gemcitabine alone for elderly or unfit advanced non-small-cell lung cancer patients
por: Comella, P, et al.
Publicado: (2004)

Homeostatic Maintenance of Allele-Specific p16 Methylation in Cancer Cells Accompanied by Dynamic Focal Methylation and Hydroxymethylation
por: Qin, Sisi, et al.
Publicado: (2014)

A panel of DNA methylated markers predicts metastasis of pN(0)M(0) gastric carcinoma: a prospective cohort study
por: Liu, Zhaojun, et al.
Publicado: (2019)

Paclitaxel for treatment of advanced small cell lung cancer (SCLC): a retrospective study of 185 patients
por: von Eiff, Damian, et al.
Publicado: (2020)

nab-Paclitaxel/Carboplatin in Vulnerable Populations With Advanced Non-Small Cell Lung Cancer: Pooled Analysis
por: Langer, Corey J., et al.
Publicado: (2021)

Immune-Related Multiple-Organs Injuries Following ICI Treatment With Tislelizumab in an Advanced Non-Small Cell Lung Cancer Patient: A Case Report
por: Deng, Chao, et al.
Publicado: (2021)

A 115-bp MethyLight assay for detection of p16 (CDKN2A) methylation as a diagnostic biomarker in human tissues
por: Zhou, Jing, et al.
Publicado: (2011)

LncRNA miR663AHG represses the development of colon cancer in a miR663a-dependent manner
por: Yuan, Hongfan, et al.
Publicado: (2023)

Phase II Clinical Trial of Genexol® (Paclitaxel) and Carboplatin for Patients with Advanced Non-small Cell Lung Cancer
por: Kim, Han Jo, et al.
Publicado: (2011)

Figitumumab combined with carboplatin and paclitaxel in treatment-naïve Japanese patients with advanced non-small cell lung cancer
por: Goto, Yasushi, et al.
Publicado: (2011)

First line treatment of advanced non-small-cell lung cancer – specific focus on albumin bound paclitaxel
por: Gupta, Neha, et al.
Publicado: (2013)

MicroRNA-7 sensitizes non-small cell lung cancer cells to paclitaxel
por: LIU, RONGHUA, et al.
Publicado: (2014)

Efficacy and safety of apatinib alone or apatinib plus paclitaxel/docetaxel versus paclitaxel/docetaxel in the treatment of advanced non‐small cell lung cancer: A meta‐analysis
por: Li, Zhe, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_1qeb9en7afv4h4vbn54q5i2e4d