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Dual Role of Autophagy in Diseases of the Central Nervous System
Autophagy is a vital lysosomal degradation and recycling pathway in the eukaryotic cell, responsible for maintaining an intricate balance between cell survival and cell death, necessary for neuronal survival and function. This dual role played by autophagy raises the question whether this process is...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548059/ https://www.ncbi.nlm.nih.gov/pubmed/31191249 http://dx.doi.org/10.3389/fncel.2019.00196 |
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author | Bar-Yosef, Tamara Damri, Odeya Agam, Galila |
author_facet | Bar-Yosef, Tamara Damri, Odeya Agam, Galila |
author_sort | Bar-Yosef, Tamara |
collection | PubMed |
description | Autophagy is a vital lysosomal degradation and recycling pathway in the eukaryotic cell, responsible for maintaining an intricate balance between cell survival and cell death, necessary for neuronal survival and function. This dual role played by autophagy raises the question whether this process is a protective or a destructive pathway, the contributor of neuronal cell death or a failed attempt to repair aberrant processes? Deregulated autophagy at different steps of the pathway, whether excessive or downregulated, has been proposed to be associated with neurodegenerative disorders such as Alzheimer’s-, Huntington’s-, and Parkinson’s-disease, known for their intracellular accumulation of protein aggregates. Recent observations of impaired autophagy also appeared in psychiatric disorders such as schizophrenia and bipolar disorder suggesting an additional contribution to the pathophysiology of mental illness. Here we review the current understanding of autophagy’s role in various neuropsychiatric disorders and, hitherto, the prevailing new potential autophagy-related therapeutic strategies for their treatment. |
format | Online Article Text |
id | pubmed-6548059 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65480592019-06-12 Dual Role of Autophagy in Diseases of the Central Nervous System Bar-Yosef, Tamara Damri, Odeya Agam, Galila Front Cell Neurosci Neuroscience Autophagy is a vital lysosomal degradation and recycling pathway in the eukaryotic cell, responsible for maintaining an intricate balance between cell survival and cell death, necessary for neuronal survival and function. This dual role played by autophagy raises the question whether this process is a protective or a destructive pathway, the contributor of neuronal cell death or a failed attempt to repair aberrant processes? Deregulated autophagy at different steps of the pathway, whether excessive or downregulated, has been proposed to be associated with neurodegenerative disorders such as Alzheimer’s-, Huntington’s-, and Parkinson’s-disease, known for their intracellular accumulation of protein aggregates. Recent observations of impaired autophagy also appeared in psychiatric disorders such as schizophrenia and bipolar disorder suggesting an additional contribution to the pathophysiology of mental illness. Here we review the current understanding of autophagy’s role in various neuropsychiatric disorders and, hitherto, the prevailing new potential autophagy-related therapeutic strategies for their treatment. Frontiers Media S.A. 2019-05-28 /pmc/articles/PMC6548059/ /pubmed/31191249 http://dx.doi.org/10.3389/fncel.2019.00196 Text en Copyright © 2019 Bar-Yosef, Damri and Agam. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Bar-Yosef, Tamara Damri, Odeya Agam, Galila Dual Role of Autophagy in Diseases of the Central Nervous System |
title | Dual Role of Autophagy in Diseases of the Central Nervous System |
title_full | Dual Role of Autophagy in Diseases of the Central Nervous System |
title_fullStr | Dual Role of Autophagy in Diseases of the Central Nervous System |
title_full_unstemmed | Dual Role of Autophagy in Diseases of the Central Nervous System |
title_short | Dual Role of Autophagy in Diseases of the Central Nervous System |
title_sort | dual role of autophagy in diseases of the central nervous system |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548059/ https://www.ncbi.nlm.nih.gov/pubmed/31191249 http://dx.doi.org/10.3389/fncel.2019.00196 |
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