Facial hyperpigmentation: Any link to cancer?

INTRODUCTION: Ectopic adrenocorticotropic hormone (ACTH) syndrome is recognized by edema, proximal muscle weakness, hypertension, diabetes and skin hyperpigmentation. This syndrome is mainly associated with malignancies. CASE PRESENTATION: A 43-year-old woman came to our hospital with a history of n...

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Detalles Bibliográficos
Autores principales: Deihim, Tina, Khajavi Rad, Nasim, Abbaszadeh, Mahsa, Karimpour Reyhan, Sahar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548085/
https://www.ncbi.nlm.nih.gov/pubmed/31172120
http://dx.doi.org/10.22114/AJEM.v0i0.98
Descripción
Sumario:INTRODUCTION: Ectopic adrenocorticotropic hormone (ACTH) syndrome is recognized by edema, proximal muscle weakness, hypertension, diabetes and skin hyperpigmentation. This syndrome is mainly associated with malignancies. CASE PRESENTATION: A 43-year-old woman came to our hospital with a history of new-onset diabetes, hypertension, edema and facial hyperpigmentation from four months before. Upon admission, she had alkalosis, hypokalemia, mild hypertension and low-grade fever. Due to abdominal pain, an abdominal ultrasound was performed, which revealed common bile duct (CBD) and pancreatic duct dilation. The abdominopelvic computed tomography (CT) scan showed a poorly-enhancing mass in the periampullary region. CONCLUSION: The patient's facial hyperpigmentation and hypokalemia appear to have been due to ACTH ectopic syndrome as a result of periampullary cancer.

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