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Bayonets over bombs: RIPK3 and MLKL restrict Listeria without triggering necroptosis
RIPK3 induces necroptosis by phosphorylating MLKL, which then induces plasma membrane rupture and necrotic cell death. In this issue, Sai et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201810014) show that RIPK3-MLKL signaling in epithelial cells promotes Listeria clearance by directly supp...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548124/ https://www.ncbi.nlm.nih.gov/pubmed/31097456 http://dx.doi.org/10.1083/jcb.201905047 |
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author | Zhang, Ting Balachandran, Siddharth |
author_facet | Zhang, Ting Balachandran, Siddharth |
author_sort | Zhang, Ting |
collection | PubMed |
description | RIPK3 induces necroptosis by phosphorylating MLKL, which then induces plasma membrane rupture and necrotic cell death. In this issue, Sai et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201810014) show that RIPK3-MLKL signaling in epithelial cells promotes Listeria clearance by directly suppressing cytosolic bacterial replication, without activating cell death. |
format | Online Article Text |
id | pubmed-6548124 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-65481242019-12-28 Bayonets over bombs: RIPK3 and MLKL restrict Listeria without triggering necroptosis Zhang, Ting Balachandran, Siddharth J Cell Biol Commentaries RIPK3 induces necroptosis by phosphorylating MLKL, which then induces plasma membrane rupture and necrotic cell death. In this issue, Sai et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201810014) show that RIPK3-MLKL signaling in epithelial cells promotes Listeria clearance by directly suppressing cytosolic bacterial replication, without activating cell death. Rockefeller University Press 2019-06-28 2019-05-16 /pmc/articles/PMC6548124/ /pubmed/31097456 http://dx.doi.org/10.1083/jcb.201905047 Text en © 2019 Zhang and Balachandran http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Commentaries Zhang, Ting Balachandran, Siddharth Bayonets over bombs: RIPK3 and MLKL restrict Listeria without triggering necroptosis |
title | Bayonets over bombs: RIPK3 and MLKL restrict Listeria without triggering necroptosis |
title_full | Bayonets over bombs: RIPK3 and MLKL restrict Listeria without triggering necroptosis |
title_fullStr | Bayonets over bombs: RIPK3 and MLKL restrict Listeria without triggering necroptosis |
title_full_unstemmed | Bayonets over bombs: RIPK3 and MLKL restrict Listeria without triggering necroptosis |
title_short | Bayonets over bombs: RIPK3 and MLKL restrict Listeria without triggering necroptosis |
title_sort | bayonets over bombs: ripk3 and mlkl restrict listeria without triggering necroptosis |
topic | Commentaries |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548124/ https://www.ncbi.nlm.nih.gov/pubmed/31097456 http://dx.doi.org/10.1083/jcb.201905047 |
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