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Bayonets over bombs: RIPK3 and MLKL restrict Listeria without triggering necroptosis

RIPK3 induces necroptosis by phosphorylating MLKL, which then induces plasma membrane rupture and necrotic cell death. In this issue, Sai et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201810014) show that RIPK3-MLKL signaling in epithelial cells promotes Listeria clearance by directly supp...

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Detalles Bibliográficos
Autores principales: Zhang, Ting, Balachandran, Siddharth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548124/
https://www.ncbi.nlm.nih.gov/pubmed/31097456
http://dx.doi.org/10.1083/jcb.201905047
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author Zhang, Ting
Balachandran, Siddharth
author_facet Zhang, Ting
Balachandran, Siddharth
author_sort Zhang, Ting
collection PubMed
description RIPK3 induces necroptosis by phosphorylating MLKL, which then induces plasma membrane rupture and necrotic cell death. In this issue, Sai et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201810014) show that RIPK3-MLKL signaling in epithelial cells promotes Listeria clearance by directly suppressing cytosolic bacterial replication, without activating cell death.
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spelling pubmed-65481242019-12-28 Bayonets over bombs: RIPK3 and MLKL restrict Listeria without triggering necroptosis Zhang, Ting Balachandran, Siddharth J Cell Biol Commentaries RIPK3 induces necroptosis by phosphorylating MLKL, which then induces plasma membrane rupture and necrotic cell death. In this issue, Sai et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201810014) show that RIPK3-MLKL signaling in epithelial cells promotes Listeria clearance by directly suppressing cytosolic bacterial replication, without activating cell death. Rockefeller University Press 2019-06-28 2019-05-16 /pmc/articles/PMC6548124/ /pubmed/31097456 http://dx.doi.org/10.1083/jcb.201905047 Text en © 2019 Zhang and Balachandran http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentaries
Zhang, Ting
Balachandran, Siddharth
Bayonets over bombs: RIPK3 and MLKL restrict Listeria without triggering necroptosis
title Bayonets over bombs: RIPK3 and MLKL restrict Listeria without triggering necroptosis
title_full Bayonets over bombs: RIPK3 and MLKL restrict Listeria without triggering necroptosis
title_fullStr Bayonets over bombs: RIPK3 and MLKL restrict Listeria without triggering necroptosis
title_full_unstemmed Bayonets over bombs: RIPK3 and MLKL restrict Listeria without triggering necroptosis
title_short Bayonets over bombs: RIPK3 and MLKL restrict Listeria without triggering necroptosis
title_sort bayonets over bombs: ripk3 and mlkl restrict listeria without triggering necroptosis
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548124/
https://www.ncbi.nlm.nih.gov/pubmed/31097456
http://dx.doi.org/10.1083/jcb.201905047
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