Cargando…
Mutant p53 amplifies a dynamin-1/APPL1 endosome feedback loop that regulates recycling and migration
Multiple mechanisms contribute to cancer cell progression and metastatic activity, including changes in endocytic trafficking and signaling of cell surface receptors downstream of gain-of-function (GOF) mutant p53. We report that dynamin-1 (Dyn1) is up-regulated at both the mRNA and protein levels i...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548126/ https://www.ncbi.nlm.nih.gov/pubmed/31043431 http://dx.doi.org/10.1083/jcb.201810183 |