Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition

Inhibition of histone deacetylase 6 (HDAC6) was shown to support axon growth on the nonpermissive substrates myelin-associated glycoprotein (MAG) and chondroitin sulfate proteoglycans (CSPGs). Though HDAC6 deacetylates α-tubulin, we find that another HDAC6 substrate contributes to this axon growth f...

Descripción completa

Detalles Bibliográficos
Autores principales: Kalinski, Ashley L., Kar, Amar N., Craver, John, Tosolini, Andrew P., Sleigh, James N., Lee, Seung Joon, Hawthorne, Alicia, Brito-Vargas, Paul, Miller-Randolph, Sharmina, Passino, Ryan, Shi, Liang, Wong, Victor S.C., Picci, Cristina, Smith, Deanna S., Willis, Dianna E., Havton, Leif A., Schiavo, Giampietro, Giger, Roman J., Langley, Brett, Twiss, Jeffery L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548128/
https://www.ncbi.nlm.nih.gov/pubmed/31068376
http://dx.doi.org/10.1083/jcb.201702187

Ejemplares similares

Ejemplares similares