West Nile Virus Encephalitis in Haematological Setting: Report of Two Cases and a Brief Review of the Literature

West Nile virus is a zoonotic agent causing life-threatening encephalitis in a proportion of infected patients. Older age, immunosuppression, and mutations in specific host genes (e.g., CCR5 delta-32 mutation) predispose to neuroinvasive infection. We report on two cases of severe West Nile encephal...

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Detalles Bibliográficos
Autores principales: Ferrarini, Isacco, Rigo, Antonella, Gandini, Alberto, Vinante, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Università Cattolica del Sacro Cuore 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548214/
https://www.ncbi.nlm.nih.gov/pubmed/31205637
http://dx.doi.org/10.4084/MJHID.2019.033
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author Ferrarini, Isacco
Rigo, Antonella
Gandini, Alberto
Vinante, Fabrizio
author_facet Ferrarini, Isacco
Rigo, Antonella
Gandini, Alberto
Vinante, Fabrizio
author_sort Ferrarini, Isacco
collection PubMed
description West Nile virus is a zoonotic agent causing life-threatening encephalitis in a proportion of infected patients. Older age, immunosuppression, and mutations in specific host genes (e.g., CCR5 delta-32 mutation) predispose to neuroinvasive infection. We report on two cases of severe West Nile encephalitis in recently-treated, different-aged, chronic lymphocytic leukemia patients. Both patients developed high-grade fever associated with severe neurological impairment. The younger one harboured germ-line CCR5 delta-32 mutation, which might have played a role in the pathogenesis of its neuroinvasive manifestations.
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spelling pubmed-65482142019-06-14 West Nile Virus Encephalitis in Haematological Setting: Report of Two Cases and a Brief Review of the Literature Ferrarini, Isacco Rigo, Antonella Gandini, Alberto Vinante, Fabrizio Mediterr J Hematol Infect Dis Case Report West Nile virus is a zoonotic agent causing life-threatening encephalitis in a proportion of infected patients. Older age, immunosuppression, and mutations in specific host genes (e.g., CCR5 delta-32 mutation) predispose to neuroinvasive infection. We report on two cases of severe West Nile encephalitis in recently-treated, different-aged, chronic lymphocytic leukemia patients. Both patients developed high-grade fever associated with severe neurological impairment. The younger one harboured germ-line CCR5 delta-32 mutation, which might have played a role in the pathogenesis of its neuroinvasive manifestations. Università Cattolica del Sacro Cuore 2019-05-01 /pmc/articles/PMC6548214/ /pubmed/31205637 http://dx.doi.org/10.4084/MJHID.2019.033 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0), which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited.
spellingShingle Case Report
Ferrarini, Isacco
Rigo, Antonella
Gandini, Alberto
Vinante, Fabrizio
West Nile Virus Encephalitis in Haematological Setting: Report of Two Cases and a Brief Review of the Literature
title West Nile Virus Encephalitis in Haematological Setting: Report of Two Cases and a Brief Review of the Literature
title_full West Nile Virus Encephalitis in Haematological Setting: Report of Two Cases and a Brief Review of the Literature
title_fullStr West Nile Virus Encephalitis in Haematological Setting: Report of Two Cases and a Brief Review of the Literature
title_full_unstemmed West Nile Virus Encephalitis in Haematological Setting: Report of Two Cases and a Brief Review of the Literature
title_short West Nile Virus Encephalitis in Haematological Setting: Report of Two Cases and a Brief Review of the Literature
title_sort west nile virus encephalitis in haematological setting: report of two cases and a brief review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548214/
https://www.ncbi.nlm.nih.gov/pubmed/31205637
http://dx.doi.org/10.4084/MJHID.2019.033
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