In vitro efficacy of gentamicin released from collagen sponge in eradication of bacterial biofilm preformed on hydroxyapatite surface

Biofilm-related infections of bones pose a significant therapeutic issue. In this article we present in vitro results of the efficacy of gentamicin released from a collagen sponge carrier against Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae biofilms preformed on hydroxyapa...

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Autores principales: Maczynska, Beata, Secewicz, Anna, Smutnicka, Danuta, Szymczyk, Patrycja, Dudek-Wicher, Ruth, Junka, Adam, Bartoszewicz, Marzenna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548372/
https://www.ncbi.nlm.nih.gov/pubmed/31163049
http://dx.doi.org/10.1371/journal.pone.0217769
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author Maczynska, Beata
Secewicz, Anna
Smutnicka, Danuta
Szymczyk, Patrycja
Dudek-Wicher, Ruth
Junka, Adam
Bartoszewicz, Marzenna
author_facet Maczynska, Beata
Secewicz, Anna
Smutnicka, Danuta
Szymczyk, Patrycja
Dudek-Wicher, Ruth
Junka, Adam
Bartoszewicz, Marzenna
author_sort Maczynska, Beata
collection PubMed
description Biofilm-related infections of bones pose a significant therapeutic issue. In this article we present in vitro results of the efficacy of gentamicin released from a collagen sponge carrier against Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae biofilms preformed on hydroxyapatite surface. The results indicate that high local concentrations of gentamicin released from a sponge eradicate the biofilm formed not only by gentamicin-sensitive strains but, to some extent, also by those that display a resistance pattern in routine diagnostics. The data presented in this paper is of high clinical translational value and may find application in the treatment of bone infections.
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spelling pubmed-65483722019-06-17 In vitro efficacy of gentamicin released from collagen sponge in eradication of bacterial biofilm preformed on hydroxyapatite surface Maczynska, Beata Secewicz, Anna Smutnicka, Danuta Szymczyk, Patrycja Dudek-Wicher, Ruth Junka, Adam Bartoszewicz, Marzenna PLoS One Research Article Biofilm-related infections of bones pose a significant therapeutic issue. In this article we present in vitro results of the efficacy of gentamicin released from a collagen sponge carrier against Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae biofilms preformed on hydroxyapatite surface. The results indicate that high local concentrations of gentamicin released from a sponge eradicate the biofilm formed not only by gentamicin-sensitive strains but, to some extent, also by those that display a resistance pattern in routine diagnostics. The data presented in this paper is of high clinical translational value and may find application in the treatment of bone infections. Public Library of Science 2019-06-04 /pmc/articles/PMC6548372/ /pubmed/31163049 http://dx.doi.org/10.1371/journal.pone.0217769 Text en © 2019 Maczynska et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Maczynska, Beata
Secewicz, Anna
Smutnicka, Danuta
Szymczyk, Patrycja
Dudek-Wicher, Ruth
Junka, Adam
Bartoszewicz, Marzenna
In vitro efficacy of gentamicin released from collagen sponge in eradication of bacterial biofilm preformed on hydroxyapatite surface
title In vitro efficacy of gentamicin released from collagen sponge in eradication of bacterial biofilm preformed on hydroxyapatite surface
title_full In vitro efficacy of gentamicin released from collagen sponge in eradication of bacterial biofilm preformed on hydroxyapatite surface
title_fullStr In vitro efficacy of gentamicin released from collagen sponge in eradication of bacterial biofilm preformed on hydroxyapatite surface
title_full_unstemmed In vitro efficacy of gentamicin released from collagen sponge in eradication of bacterial biofilm preformed on hydroxyapatite surface
title_short In vitro efficacy of gentamicin released from collagen sponge in eradication of bacterial biofilm preformed on hydroxyapatite surface
title_sort in vitro efficacy of gentamicin released from collagen sponge in eradication of bacterial biofilm preformed on hydroxyapatite surface
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548372/
https://www.ncbi.nlm.nih.gov/pubmed/31163049
http://dx.doi.org/10.1371/journal.pone.0217769
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