cGAS-independent STING activation in response to DNA damage

Self-DNA has previously been thought to be protected from immune detection by compartmentalisation in the nucleus or mitochondria. Here, we describe the discovery of a signalling cascade that links the detection of DNA damage in the nucleus to the activation of the innate immune adaptor STING (STimu...

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Detalles Bibliográficos
Autores principales: Unterholzner, Leonie, Dunphy, Gillian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548478/
https://www.ncbi.nlm.nih.gov/pubmed/31211228
http://dx.doi.org/10.1080/23723556.2018.1558682
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author Unterholzner, Leonie
Dunphy, Gillian
author_facet Unterholzner, Leonie
Dunphy, Gillian
author_sort Unterholzner, Leonie
collection PubMed
description Self-DNA has previously been thought to be protected from immune detection by compartmentalisation in the nucleus or mitochondria. Here, we describe the discovery of a signalling cascade that links the detection of DNA damage in the nucleus to the activation of the innate immune adaptor STING (STimulator of INterfern Genes).
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spelling pubmed-65484782020-04-19 cGAS-independent STING activation in response to DNA damage Unterholzner, Leonie Dunphy, Gillian Mol Cell Oncol Author's Views Self-DNA has previously been thought to be protected from immune detection by compartmentalisation in the nucleus or mitochondria. Here, we describe the discovery of a signalling cascade that links the detection of DNA damage in the nucleus to the activation of the innate immune adaptor STING (STimulator of INterfern Genes). Taylor & Francis 2019-04-19 /pmc/articles/PMC6548478/ /pubmed/31211228 http://dx.doi.org/10.1080/23723556.2018.1558682 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Unterholzner, Leonie
Dunphy, Gillian
cGAS-independent STING activation in response to DNA damage
title cGAS-independent STING activation in response to DNA damage
title_full cGAS-independent STING activation in response to DNA damage
title_fullStr cGAS-independent STING activation in response to DNA damage
title_full_unstemmed cGAS-independent STING activation in response to DNA damage
title_short cGAS-independent STING activation in response to DNA damage
title_sort cgas-independent sting activation in response to dna damage
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548478/
https://www.ncbi.nlm.nih.gov/pubmed/31211228
http://dx.doi.org/10.1080/23723556.2018.1558682
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