JmjC histone demethylases act as chromatin oxygen sensors

Oxygen sensing is important in physiology but also in disease. We find that hypoxia (oxygen deficiency) triggers rapid and hypoxia-inducible factor (HIF)-independent histone methylation changes which are reversible upon reoxygenation. Hypoxia-induced histone methylation genomic distribution precedes...

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Detalles Bibliográficos
Autores principales: Batie, Michael, Rocha, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548480/
https://www.ncbi.nlm.nih.gov/pubmed/31211238
http://dx.doi.org/10.1080/23723556.2019.1608501
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author Batie, Michael
Rocha, Sonia
author_facet Batie, Michael
Rocha, Sonia
author_sort Batie, Michael
collection PubMed
description Oxygen sensing is important in physiology but also in disease. We find that hypoxia (oxygen deficiency) triggers rapid and hypoxia-inducible factor (HIF)-independent histone methylation changes which are reversible upon reoxygenation. Hypoxia-induced histone methylation genomic distribution precedes transcriptional changes and is mimicked by specific Jumonji-C (JmjC) histone demethylase depletion. Oxygen sensing by JmjC histone demethylases is required for the cellular response to hypoxia.
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spelling pubmed-65484802020-05-07 JmjC histone demethylases act as chromatin oxygen sensors Batie, Michael Rocha, Sonia Mol Cell Oncol Author's Views Oxygen sensing is important in physiology but also in disease. We find that hypoxia (oxygen deficiency) triggers rapid and hypoxia-inducible factor (HIF)-independent histone methylation changes which are reversible upon reoxygenation. Hypoxia-induced histone methylation genomic distribution precedes transcriptional changes and is mimicked by specific Jumonji-C (JmjC) histone demethylase depletion. Oxygen sensing by JmjC histone demethylases is required for the cellular response to hypoxia. Taylor & Francis 2019-05-07 /pmc/articles/PMC6548480/ /pubmed/31211238 http://dx.doi.org/10.1080/23723556.2019.1608501 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Author's Views
Batie, Michael
Rocha, Sonia
JmjC histone demethylases act as chromatin oxygen sensors
title JmjC histone demethylases act as chromatin oxygen sensors
title_full JmjC histone demethylases act as chromatin oxygen sensors
title_fullStr JmjC histone demethylases act as chromatin oxygen sensors
title_full_unstemmed JmjC histone demethylases act as chromatin oxygen sensors
title_short JmjC histone demethylases act as chromatin oxygen sensors
title_sort jmjc histone demethylases act as chromatin oxygen sensors
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548480/
https://www.ncbi.nlm.nih.gov/pubmed/31211238
http://dx.doi.org/10.1080/23723556.2019.1608501
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