Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells

A genome-wide small-interfering RNA-based screen identified the transcription factor Specificity Protein 3 (SP3) as a critical factor for Second mitochondrial-derived activator of caspase (Smac) mimetic-mediated killing of cancer cells. In concert with Nuclear Factor kappa B (NF-κB,) SP3 is required...

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Detalles Bibliográficos
Autores principales: Beug, Shawn T., Korneluk, Robert G., LaCasse, Eric C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548490/
https://www.ncbi.nlm.nih.gov/pubmed/31211235
http://dx.doi.org/10.1080/23723556.2019.1607456
Descripción
Sumario:A genome-wide small-interfering RNA-based screen identified the transcription factor Specificity Protein 3 (SP3) as a critical factor for Second mitochondrial-derived activator of caspase (Smac) mimetic-mediated killing of cancer cells. In concert with Nuclear Factor kappa B (NF-κB,) SP3 is required for the expression of the cytokine Tumor Necrosis Factor alpha (TNF-α) under basal and Smac mimetic-stimulated conditions.

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