Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells

A genome-wide small-interfering RNA-based screen identified the transcription factor Specificity Protein 3 (SP3) as a critical factor for Second mitochondrial-derived activator of caspase (Smac) mimetic-mediated killing of cancer cells. In concert with Nuclear Factor kappa B (NF-κB,) SP3 is required...

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Autores principales: Beug, Shawn T., Korneluk, Robert G., LaCasse, Eric C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548490/
https://www.ncbi.nlm.nih.gov/pubmed/31211235
http://dx.doi.org/10.1080/23723556.2019.1607456
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author Beug, Shawn T.
Korneluk, Robert G.
LaCasse, Eric C.
author_facet Beug, Shawn T.
Korneluk, Robert G.
LaCasse, Eric C.
author_sort Beug, Shawn T.
collection PubMed
description A genome-wide small-interfering RNA-based screen identified the transcription factor Specificity Protein 3 (SP3) as a critical factor for Second mitochondrial-derived activator of caspase (Smac) mimetic-mediated killing of cancer cells. In concert with Nuclear Factor kappa B (NF-κB,) SP3 is required for the expression of the cytokine Tumor Necrosis Factor alpha (TNF-α) under basal and Smac mimetic-stimulated conditions.
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spelling pubmed-65484902020-05-08 Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells Beug, Shawn T. Korneluk, Robert G. LaCasse, Eric C. Mol Cell Oncol Author's Views A genome-wide small-interfering RNA-based screen identified the transcription factor Specificity Protein 3 (SP3) as a critical factor for Second mitochondrial-derived activator of caspase (Smac) mimetic-mediated killing of cancer cells. In concert with Nuclear Factor kappa B (NF-κB,) SP3 is required for the expression of the cytokine Tumor Necrosis Factor alpha (TNF-α) under basal and Smac mimetic-stimulated conditions. Taylor & Francis 2019-05-08 /pmc/articles/PMC6548490/ /pubmed/31211235 http://dx.doi.org/10.1080/23723556.2019.1607456 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Beug, Shawn T.
Korneluk, Robert G.
LaCasse, Eric C.
Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells
title Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells
title_full Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells
title_fullStr Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells
title_full_unstemmed Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells
title_short Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells
title_sort sp3-cificity of tnf-α expression promotes the smac mimetic-mediated killing of cancer cells
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548490/
https://www.ncbi.nlm.nih.gov/pubmed/31211235
http://dx.doi.org/10.1080/23723556.2019.1607456
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