Intrinsic Cleavage of RNA Polymerase II Adopts a Nucleobase-independent Mechanism Assisted by Transcript Phosphate

RNA polymerase II (Pol II) utilises the same active site for polymerization and intrinsic cleavage. Pol II proofreads the nascent transcript by its intrinsic nuclease activity to maintain high transcriptional fidelity critical for cell growth and viability. The detailed catalytic mechanism of intrin...

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Detalles Bibliográficos
Autores principales: Ka Man Tse, Carmen, Xu, Jun, Xu, Liang, Sheong, Fu Kit, Wang, Shenglong, Chow, Hoi Yee, Gao, Xin, Li, Xuechen, Cheung, Peter Pak-Hang, Wang, Dong, Zhang, Yingkai, Huang, Xuhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548511/
https://www.ncbi.nlm.nih.gov/pubmed/31179024
http://dx.doi.org/10.1038/s41929-019-0227-5

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