A transcriptome-wide association study of high grade serous epithelial ovarian cancer identifies novel susceptibility genes and splice variants

We sought to identify susceptibility genes for high-grade serous ovarian cancer (HGSOC) by performing a transcriptome-wide association study (TWAS) of gene expression and splice junction usage in HGSOC-relevant tissue types (N = 2,169) and the largest GWAS available for HGSOC (N = 13,037 cases/40,94...

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Detalles Bibliográficos
Autores principales: Gusev, Alexander, Lawrenson, Kate, Lin, Xianzhi, Lyra, Paulo C., Kar, Siddhartha, Vavra, Kevin C., Segato, Felipe, Fonseca, Marcos A.S., Lee, Janet M, Pejovic, Tanya, Liu, Gang, Karlan, Beth Y., Freedman, Matthew L., Noushmehr, Houtan, Monteiro, Alvaro N., Pharoah, Paul D.P., Pasaniuc, Bogdan, Gayther, Simon A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548545/
https://www.ncbi.nlm.nih.gov/pubmed/31043753
http://dx.doi.org/10.1038/s41588-019-0395-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548545/
https://www.ncbi.nlm.nih.gov/pubmed/31043753
http://dx.doi.org/10.1038/s41588-019-0395-x

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