Integrated Regulation of HuR by Translation Repression and Protein Degradation Determines Pulsatile Expression of p53 Under DNA Damage

Expression of tumor suppressor p53 is regulated at multiple levels, disruption of which often leads to cancer. We have adopted an approach combining computational systems modeling with experimental validation to elucidate the translation regulatory network that controls p53 expression post DNA damag...

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Detalles Bibliográficos
Autores principales: Guha, Abhishek, Ahuja, Deepika, Das Mandal, Sukhen, Parasar, Bibudha, Deyasi, Krishanu, Roy, Debadrita, Sharma, Vasundhara, Willard, Belinda, Ghosh, Anandamohan, Ray, Partho Sarothi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548907/
https://www.ncbi.nlm.nih.gov/pubmed/31103853
http://dx.doi.org/10.1016/j.isci.2019.05.002

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