Developing ABEmax-NG with Precise Targeting and Expanded Editing Scope to Model Pathogenic Splice Site Mutations In Vivo

RNA splicing is related to many human diseases; however, lack of efficient genetic approaches to modulate splicing has prevented us from dissecting their functions in human diseases. Recently developed base editors (BEs) offer a new strategy to modulate RNA splicing by converting conservative splice...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Shisheng, Liao, Zhaodi, Li, Xiangyang, Liu, Zhen, Li, Guanglei, Li, Jianan, Lu, Zongyang, Zhang, Yu, Li, Xiajun, Ma, Xu, Sun, Qiang, Huang, Xingxu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548941/
https://www.ncbi.nlm.nih.gov/pubmed/31130518
http://dx.doi.org/10.1016/j.isci.2019.05.008

Ejemplares similares

Ejemplares similares