Cargando…

Stimulation and Repair of Peripheral Nerves Using Bioadhesive Graft‐Antenna

An original wireless stimulator for peripheral nerves based on a metal loop (diameter ≈1 mm) that is powered by a transcranial magnetic stimulator (TMS) and does not require circuitry components is reported. The loop can be integrated in a chitosan scaffold that functions as a graft when applied ont...

Descripción completa

Detalles Bibliográficos
Autores principales: Sliow, Ashour, Ma, Zhi, Gargiulo, Gaetano, Mahns, David, Mawad, Damia, Breen, Paul, Stoodley, Marcus, Houang, Jessica, Kuchel, Rhiannon, Tettamanzi, Giuseppe C., Tilley, Richard D., Frost, Samuel J., Morley, John, Longo, Leonardo, Lauto, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548953/
https://www.ncbi.nlm.nih.gov/pubmed/31179205
http://dx.doi.org/10.1002/advs.201801212
Descripción
Sumario:An original wireless stimulator for peripheral nerves based on a metal loop (diameter ≈1 mm) that is powered by a transcranial magnetic stimulator (TMS) and does not require circuitry components is reported. The loop can be integrated in a chitosan scaffold that functions as a graft when applied onto transected nerves (graft‐antenna). The graft‐antenna is bonded to rat sciatic nerves by a laser without sutures; it does not migrate after implantation and is able to trigger steady compound muscle action potentials for 12 weeks (CMAP ≈1.3 mV). Eight weeks postoperatively, axon regeneration is facilitated in transected nerves that are repaired with the graft‐antenna and stimulated by the TMS for 1 h per week. The graft‐antenna is an innovative and minimally‐invasive device that functions concurrently as a wireless stimulator and adhesive scaffold for nerve repair.