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Antibacterial coating of implants: are we missing something?

Implant-related infection is one of the leading reasons for failure in orthopaedics and trauma, and results in high social and economic costs. Various antibacterial coating technologies have proven to be safe and effective both in preclinical and clinical studies, with post-surgical implant-related...

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Autores principales: Romanò, C. L., Tsuchiya, H., Morelli, I., Battaglia, A. G., Drago, L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548976/
https://www.ncbi.nlm.nih.gov/pubmed/31214332
http://dx.doi.org/10.1302/2046-3758.85.BJR-2018-0316
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author Romanò, C. L.
Tsuchiya, H.
Morelli, I.
Battaglia, A. G.
Drago, L.
author_facet Romanò, C. L.
Tsuchiya, H.
Morelli, I.
Battaglia, A. G.
Drago, L.
author_sort Romanò, C. L.
collection PubMed
description Implant-related infection is one of the leading reasons for failure in orthopaedics and trauma, and results in high social and economic costs. Various antibacterial coating technologies have proven to be safe and effective both in preclinical and clinical studies, with post-surgical implant-related infections reduced by 90% in some cases, depending on the type of coating and experimental setup used. Economic assessment may enable the cost-to-benefit profile of any given antibacterial coating to be defined, based on the expected infection rate with and without the coating, the cost of the infection management, and the cost of the coating. After reviewing the latest evidence on the available antibacterial coatings, we quantified the impact caused by delaying their large-scale application. Considering only joint arthroplasties, our calculations indicated that for an antibacterial coating, with a final user’s cost price of €600 and able to reduce post-surgical infection by 80%, each year of delay to its large-scale application would cause an estimated 35 200 new cases of post-surgical infection in Europe, equating to additional hospital costs of approximately €440 million per year. An adequate reimbursement policy for antibacterial coatings may benefit patients, healthcare systems, and related research, as could faster and more affordable regulatory pathways for the technologies still in the pipeline. This could significantly reduce the social and economic burden of implant-related infections in orthopaedics and trauma. Cite this article: C. L. Romanò, H. Tsuchiya, I. Morelli, A. G. Battaglia, L. Drago. Antibacterial coating of implants: are we missing something? Bone Joint Res 2019;8:199–206. DOI: 10.1302/2046-3758.85.BJR-2018-0316.
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spelling pubmed-65489762019-06-18 Antibacterial coating of implants: are we missing something? Romanò, C. L. Tsuchiya, H. Morelli, I. Battaglia, A. G. Drago, L. Bone Joint Res Infection Implant-related infection is one of the leading reasons for failure in orthopaedics and trauma, and results in high social and economic costs. Various antibacterial coating technologies have proven to be safe and effective both in preclinical and clinical studies, with post-surgical implant-related infections reduced by 90% in some cases, depending on the type of coating and experimental setup used. Economic assessment may enable the cost-to-benefit profile of any given antibacterial coating to be defined, based on the expected infection rate with and without the coating, the cost of the infection management, and the cost of the coating. After reviewing the latest evidence on the available antibacterial coatings, we quantified the impact caused by delaying their large-scale application. Considering only joint arthroplasties, our calculations indicated that for an antibacterial coating, with a final user’s cost price of €600 and able to reduce post-surgical infection by 80%, each year of delay to its large-scale application would cause an estimated 35 200 new cases of post-surgical infection in Europe, equating to additional hospital costs of approximately €440 million per year. An adequate reimbursement policy for antibacterial coatings may benefit patients, healthcare systems, and related research, as could faster and more affordable regulatory pathways for the technologies still in the pipeline. This could significantly reduce the social and economic burden of implant-related infections in orthopaedics and trauma. Cite this article: C. L. Romanò, H. Tsuchiya, I. Morelli, A. G. Battaglia, L. Drago. Antibacterial coating of implants: are we missing something? Bone Joint Res 2019;8:199–206. DOI: 10.1302/2046-3758.85.BJR-2018-0316. 2019-06-05 /pmc/articles/PMC6548976/ /pubmed/31214332 http://dx.doi.org/10.1302/2046-3758.85.BJR-2018-0316 Text en © 2019 Author(s) et al. This is an open-access article distributed under the terms of the Creative Commons Attributions licence (CC-BY-NC), which permits unrestricted use, distribution, and reproduction in any medium, but not for commercial gain, provided the original author and source are credited.
spellingShingle Infection
Romanò, C. L.
Tsuchiya, H.
Morelli, I.
Battaglia, A. G.
Drago, L.
Antibacterial coating of implants: are we missing something?
title Antibacterial coating of implants: are we missing something?
title_full Antibacterial coating of implants: are we missing something?
title_fullStr Antibacterial coating of implants: are we missing something?
title_full_unstemmed Antibacterial coating of implants: are we missing something?
title_short Antibacterial coating of implants: are we missing something?
title_sort antibacterial coating of implants: are we missing something?
topic Infection
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548976/
https://www.ncbi.nlm.nih.gov/pubmed/31214332
http://dx.doi.org/10.1302/2046-3758.85.BJR-2018-0316
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AT dragol antibacterialcoatingofimplantsarewemissingsomething