Cargando…
Metformin treatment reduces motor and neuropsychiatric phenotypes in the zQ175 mouse model of Huntington disease
Huntington disease is a neurodegenerative condition for which there is no cure to date. Activation of AMP-activated protein kinase has previously been shown to be beneficial in in vitro and in vivo models of Huntington’s disease. Moreover, a recent cross-sectional study demonstrated that treatment w...
Autores principales: | Sanchis, Ana, García-Gimeno, María Adelaida, Cañada-Martínez, Antonio José, Sequedo, María Dolores, Millán, José María, Sanz, Pascual, Vázquez-Manrique, Rafael P. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549163/ https://www.ncbi.nlm.nih.gov/pubmed/31165723 http://dx.doi.org/10.1038/s12276-019-0264-9 |
Ejemplares similares
-
Abnormal Brain Development in Huntington’ Disease Is Recapitulated in the zQ175 Knock-In Mouse Model
por: Zhang, Chuangchuang, et al.
Publicado: (2020) -
Enhanced GABAergic Inhibition of Cholinergic Interneurons in the zQ175(+/−) Mouse Model of Huntington's Disease
por: Lim, Sean Austin O., et al.
Publicado: (2021) -
The Urine Metabolome of R6/2 and zQ175DN Huntington’s Disease Mouse Models
por: Speziale, Roberto, et al.
Publicado: (2023) -
Comprehensive Behavioral and Molecular Characterization of a New Knock-In Mouse Model of Huntington’s Disease: zQ175
por: Menalled, Liliana B., et al.
Publicado: (2012) -
Characterization of Behavioral, Neuropathological, Brain Metabolic and Key Molecular Changes in zQ175 Knock-In Mouse Model of Huntington’s Disease
por: Peng, Qi, et al.
Publicado: (2016)