Cargando…

Protein kinase A inhibits tumor mutator APOBEC3B through phosphorylation

APOBEC3B cytidine deaminase (A3B) catalyzes cytosine into uracil in single-strand DNA and induces C-to-T mutations in genomic DNA of various types of tumors. Accumulation of APOBEC signature mutations is correlated with a worse prognosis for patients with breast cancer or multiple myeloma, suggestin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Matsumoto, Tadahiko, Shirakawa, Kotaro, Yokoyama, Masaru, Fukuda, Hirofumi, Sarca, Anamaria Daniela, Koyabu, Sukenao, Yamazaki, Hiroyuki, Kazuma, Yasuhiro, Matsui, Hiroyuki, Maruyama, Wataru, Nagata, Kayoko, Tanabe, Fumiko, Kobayashi, Masayuki, Shindo, Keisuke, Morishita, Ryo, Sato, Hironori, Takaori-Kondo, Akifumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549188/ https://www.ncbi.nlm.nih.gov/pubmed/31165764 http://dx.doi.org/10.1038/s41598-019-44407-9

Ejemplares similares

APOBEC3B reporter myeloma cell lines identify DNA damage response pathways leading to APOBEC3B expression
por: Yamazaki, Hiroyuki, et al.
Publicado: (2020)

Endogenous APOBEC3B Overexpression Constitutively Generates DNA Substitutions and Deletions in Myeloma Cells
por: Yamazaki, Hiroyuki, et al.
Publicado: (2019)

ILF2 enhances the DNA cytosine deaminase activity of tumor mutator APOBEC3B in multiple myeloma cells
por: Kazuma, Yasuhiro, et al.
Publicado: (2022)

FRET-Based Detection and Quantification of HIV-1 Virion Maturation
por: Sarca, Anamaria D., et al.
Publicado: (2021)

Structural Determinants of the APOBEC3G N-Terminal Domain for HIV-1 RNA Association
por: Fukuda, Hirofumi, et al.
Publicado: (2019)

CAGE-Seq Reveals that HIV-1 Latent Infection Does Not Trigger Unique Cellular Responses in a Jurkat T Cell Model
por: Matsui, Hiroyuki, et al.
Publicado: (2021)

Pituitary abscess in an HIV-1-infected patient
por: Yamazaki, Hiroyuki, et al.
Publicado: (2017)

ASK1 restores the antiviral activity of APOBEC3G by disrupting HIV-1 Vif-mediated counteraction
por: Miyakawa, Kei, et al.
Publicado: (2015)

APOBEC3G targets human T-cell leukemia virus type 1
por: Sasada, Amane, et al.
Publicado: (2005)

Small molecules that inhibit Vif-induced degradation of APOBEC3G
por: Matsui, Masashi, et al.
Publicado: (2014)

APOBEC3B can impair genomic stability by inducing base substitutions in genomic DNA in human cells
por: Shinohara, Masanobu, et al.
Publicado: (2012)

Abacavir, an anti–HIV-1 drug, targets TDP1-deficient adult T cell leukemia
por: Tada, Kohei, et al.
Publicado: (2015)

Homodimerization of APOBEC3G is required for inhibition of Alu retrotransposition
por: Iwabu, Yukie, et al.
Publicado: (2011)

HTLV-1 bZIP factor suppresses TDP1 expression through inhibition of NRF-1 in adult T-cell leukemia
por: Takiuchi, Yoko, et al.
Publicado: (2017)

Dual inhibition of the mTORC1 and mTORC2 signaling pathways is a promising therapeutic target for adult T‐cell leukemia
por: Kawata, Takahito, et al.
Publicado: (2017)

APOBEC3D and APOBEC3F Potently Promote HIV-1 Diversification and Evolution in Humanized Mouse Model
por: Sato, Kei, et al.
Publicado: (2014)

HIV-1 Vif: a guardian of the virus that opens up a new era in the research field of restriction factors
por: Takaori-Kondo, Akifumi, et al.
Publicado: (2013)

A panel of nanobodies recognizing conserved hidden clefts of all SARS-CoV-2 spike variants including Omicron
por: Maeda, Ryota, et al.
Publicado: (2022)

APOBEC3G Oligomerization Is Associated with the Inhibition of Both Alu and LINE-1 Retrotransposition
por: Koyama, Takayoshi, et al.
Publicado: (2013)

Comparison of up-front treatments for newly diagnosed immune thrombocytopenia -a systematic review and network meta-analysis
por: Arai, Yasuyuki, et al.
Publicado: (2018)

Efficacy of Dexamethasone for Acute Primary Immune Thrombocytopenia Compared to Prednisolone: A Systematic Review and Meta-analysis
por: Arai, Yasuyuki, et al.
Publicado: (2017)

Intratracheal trimerized nanobody cocktail administration suppresses weight loss and prolongs survival of SARS-CoV-2 infected mice
por: Nagata, Kayoko, et al.
Publicado: (2022)

Expression of Tim‐1 in primary CNS lymphoma
por: Kishimoto, Wataru, et al.
Publicado: (2016)

Lack of Association between Intact/Deletion Polymorphisms of the APOBEC3B Gene and HIV-1 Risk
por: Imahashi, Mayumi, et al.
Publicado: (2014)

Neutralization of the SARS-CoV-2 Mu Variant by Convalescent and Vaccine Serum
por: Uriu, Keiya, et al.
Publicado: (2021)

Genomics and computational science for virus research
por: Sato, Hironori, et al.
Publicado: (2013)

Dual inhibition of the MEK/ERK and PI3K/AKT pathways prevents pulmonary GVHD suppressing perivenulitis and bronchiolitis
por: Muranushi, Hiroyuki, et al.
Publicado: (2022)

CKIP-1 Is an Intrinsic Negative Regulator of T-Cell Activation through an Interaction with CARMA1
por: Sakamoto, Takashi, et al.
Publicado: (2014)

Prognostic value, immune signature and molecular mechanisms of the APOBEC family members APOBEC1, APOBEC3A, APOBEC3G and APOBEC3H in pancreatic adenocarcinoma
por: Duan, Yunjie, et al.
Publicado: (2022)

APOBECs and Herpesviruses
por: Cheng, Adam Z., et al.
Publicado: (2021)

MDM2 is a novel E3 ligase for HIV-1 Vif
por: Izumi, Taisuke, et al.
Publicado: (2009)

Hyperthermia using magnetite cationic liposomes for hamster osteosarcoma
por: Matsuoka, Fumiko, et al.
Publicado: (2004)

The SARS-CoV-2 spike S375F mutation characterizes the Omicron BA.1 variant
por: Kimura, Izumi, et al.
Publicado: (2022)

Concurrent development of small lymphocytic lymphoma and lung cancer: A report of two cases and a review of the literature
por: Nakao, Kensuke, et al.
Publicado: (2023)

HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis
por: Takahashi, Satoshi, et al.
Publicado: (2021)

New-onset diabetes after transplantation in tacrolimus-treated, living kidney transplantation: long-term impact and utility of the pre-transplant OGTT
por: Iida, Shoichi, et al.
Publicado: (2010)

Triethylammonium hydrogen chloranilate
por: Gotoh, Kazuma, et al.
Publicado: (2010)

Bis(triethylammonium) chloranilate
por: Gotoh, Kazuma, et al.
Publicado: (2013)

The Roles of APOBEC3G Complexes in the Incorporation of APOBEC3G into HIV-1
por: Ma, Jing, et al.
Publicado: (2013)

Expression of APOBEC3B mRNA in Primary Breast Cancer of Japanese Women
por: Tokunaga, Eriko, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_kp99i7n3j4igd1s8ar2fpdl013