High-throughput microscopy exposes a pharmacological window in which dual leucine zipper kinase inhibition preserves neuronal network connectivity

Therapeutic developments for neurodegenerative disorders are redirecting their focus to the mechanisms that contribute to neuronal connectivity and the loss thereof. Using a high-throughput microscopy pipeline that integrates morphological and functional measurements, we found that inhibition of dua...

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Detalles Bibliográficos
Autores principales: Verschuuren, Marlies, Verstraelen, Peter, García-Díaz Barriga, Gerardo, Cilissen, Ines, Coninx, Emma, Verslegers, Mieke, Larsen, Peter H., Nuydens, Rony, De Vos, Winnok H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549294/
https://www.ncbi.nlm.nih.gov/pubmed/31164177
http://dx.doi.org/10.1186/s40478-019-0741-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549294/
https://www.ncbi.nlm.nih.gov/pubmed/31164177
http://dx.doi.org/10.1186/s40478-019-0741-3

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