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CEBPE expression is an independent prognostic factor for acute myeloid leukemia

BACKGROUND: Identifying reliable predictive markers is important to make therapeutic decisions, and determine the prognosis for acute myeloid leukemia (AML) patients. However, approximately 50% patients could not be accurately predicted by existing risk factors. It is necessary to identify novel pro...

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Autores principales: Li, Kening, Du, Yuxin, Wei, Dong-Qing, Zhang, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549322/
https://www.ncbi.nlm.nih.gov/pubmed/31164135
http://dx.doi.org/10.1186/s12967-019-1944-x
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author Li, Kening
Du, Yuxin
Wei, Dong-Qing
Zhang, Fang
author_facet Li, Kening
Du, Yuxin
Wei, Dong-Qing
Zhang, Fang
author_sort Li, Kening
collection PubMed
description BACKGROUND: Identifying reliable predictive markers is important to make therapeutic decisions, and determine the prognosis for acute myeloid leukemia (AML) patients. However, approximately 50% patients could not be accurately predicted by existing risk factors. It is necessary to identify novel prognostic factors to subdivide the intermediate-risk group or patients without any cytogenetic and molecular abnormalities. METHODS: Kaplan–Meier and Cox regression were used for survival analyses in three independent AML datasets. Analyses integrating both bioinformatics and ChIP-qPCR experiments were performed to explore the role of CEBPE in regulating the expression of known prognostic factors. RESULTS: CEBPE expression was an independent predictor for both overall survival (OS) and event-free survival (EFS) of AML patients. Moreover, low-expression of CEBPE was found to be associated with high relapse rate. We also proved that differential expression of CEBPE stratified the wild-type patients of multiple genes into good and poor outcomes. In addition, the results showed that no obvious improvement was achieved by allogeneic transplantation in CEBPE high-expressed group, while the survival rate (both OS and EFS) was significantly increased in transplanted patients that with low expression of CEBPE. Finally, we found that CEBPE might regulate the expression of known prognostic factors by localizing on their promoters. CONCLUSION: Our findings indicated that CEBPE expression was an independent prognostic factor for AML survival, relapse and allogeneic transplantation, which will provide useful information for outcome prediction and therapeutic decisions. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12967-019-1944-x) contains supplementary material, which is available to authorized users.
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spelling pubmed-65493222019-06-06 CEBPE expression is an independent prognostic factor for acute myeloid leukemia Li, Kening Du, Yuxin Wei, Dong-Qing Zhang, Fang J Transl Med Research BACKGROUND: Identifying reliable predictive markers is important to make therapeutic decisions, and determine the prognosis for acute myeloid leukemia (AML) patients. However, approximately 50% patients could not be accurately predicted by existing risk factors. It is necessary to identify novel prognostic factors to subdivide the intermediate-risk group or patients without any cytogenetic and molecular abnormalities. METHODS: Kaplan–Meier and Cox regression were used for survival analyses in three independent AML datasets. Analyses integrating both bioinformatics and ChIP-qPCR experiments were performed to explore the role of CEBPE in regulating the expression of known prognostic factors. RESULTS: CEBPE expression was an independent predictor for both overall survival (OS) and event-free survival (EFS) of AML patients. Moreover, low-expression of CEBPE was found to be associated with high relapse rate. We also proved that differential expression of CEBPE stratified the wild-type patients of multiple genes into good and poor outcomes. In addition, the results showed that no obvious improvement was achieved by allogeneic transplantation in CEBPE high-expressed group, while the survival rate (both OS and EFS) was significantly increased in transplanted patients that with low expression of CEBPE. Finally, we found that CEBPE might regulate the expression of known prognostic factors by localizing on their promoters. CONCLUSION: Our findings indicated that CEBPE expression was an independent prognostic factor for AML survival, relapse and allogeneic transplantation, which will provide useful information for outcome prediction and therapeutic decisions. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12967-019-1944-x) contains supplementary material, which is available to authorized users. BioMed Central 2019-06-04 /pmc/articles/PMC6549322/ /pubmed/31164135 http://dx.doi.org/10.1186/s12967-019-1944-x Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Li, Kening
Du, Yuxin
Wei, Dong-Qing
Zhang, Fang
CEBPE expression is an independent prognostic factor for acute myeloid leukemia
title CEBPE expression is an independent prognostic factor for acute myeloid leukemia
title_full CEBPE expression is an independent prognostic factor for acute myeloid leukemia
title_fullStr CEBPE expression is an independent prognostic factor for acute myeloid leukemia
title_full_unstemmed CEBPE expression is an independent prognostic factor for acute myeloid leukemia
title_short CEBPE expression is an independent prognostic factor for acute myeloid leukemia
title_sort cebpe expression is an independent prognostic factor for acute myeloid leukemia
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549322/
https://www.ncbi.nlm.nih.gov/pubmed/31164135
http://dx.doi.org/10.1186/s12967-019-1944-x
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