The relationship between single nucleotide polymorphisms and dental implant loss: a scoping review

OBJECTIVES: The purpose of this review was to evaluate the relationship between genetic polymorphisms and dental implant loss. MATERIALS AND METHODS: All case-control studies examining single nucleotide polymorphisms (SNPs) and dental implant failure were considered. A Boolean search was conducted on PubMed and Scopus to find eligible studies. RESULTS: The initial search produced 78 results. Twenty-one studies were considered for inclusion after review and 16 were included in the final review. Twenty-two different polymorphisms were analyzed and statistically significant correlation was found for IL-4, IL-1A, IL-1B, MMP-8, and MMP-1 polymorphisms for dental implant failure. DISCUSSION: A limited number of comprehensive studies have been done in this field. Additional studies with larger sample sizes and different ethnic backgrounds need to be done to see if the results can be reproduced. Of the polymorphisms studied, the IL-4 (+33), MMP-8 (−799), MMP-1 (−519), and MMP-1 (−1607) polymorphisms show the greatest association with dental implant loss.