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Chlamydia trachomatis samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019
Since February 2019, over 160 Chlamydia trachomatis (CT) cases testing negative or equivocal by Aptima Combo 2 (AC2) but positive by Aptima CT test run with Panther instruments occurred in Finland. The AC2 test targets chlamydial 23S rRNA while the CT test targets 16S rRNA. Sequencing of 10 strains...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
European Centre for Disease Prevention and Control (ECDC)
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549458/ https://www.ncbi.nlm.nih.gov/pubmed/31164192 http://dx.doi.org/10.2807/1560-7917.ES.2019.24.22.1900298 |
| _version_ | 1783424012265717760 |
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| author | Rantakokko-Jalava, Kaisu Hokynar, Kati Hieta, Niina Keskitalo, Anniina Jokela, Pia Muotiala, Anna Jokiranta, T. Sakari Kuusela, Rutta Sarkkinen, Hannu Aittoniemi, Janne Vuorinen, Tytti Hakanen, Antti J Puolakkainen, Mirja |
| author_facet | Rantakokko-Jalava, Kaisu Hokynar, Kati Hieta, Niina Keskitalo, Anniina Jokela, Pia Muotiala, Anna Jokiranta, T. Sakari Kuusela, Rutta Sarkkinen, Hannu Aittoniemi, Janne Vuorinen, Tytti Hakanen, Antti J Puolakkainen, Mirja |
| author_sort | Rantakokko-Jalava, Kaisu |
| collection | PubMed |
| description | Since February 2019, over 160 Chlamydia trachomatis (CT) cases testing negative or equivocal by Aptima Combo 2 (AC2) but positive by Aptima CT test run with Panther instruments occurred in Finland. The AC2 test targets chlamydial 23S rRNA while the CT test targets 16S rRNA. Sequencing of 10 strains revealed a nucleotide substitution in 23S rRNA. The significance of this for the failure of the AC2 test to detect the variant is not yet known. |
| format | Online Article Text |
| id | pubmed-6549458 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | European Centre for Disease Prevention and Control (ECDC) |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-65494582019-06-17 Chlamydia trachomatis samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019 Rantakokko-Jalava, Kaisu Hokynar, Kati Hieta, Niina Keskitalo, Anniina Jokela, Pia Muotiala, Anna Jokiranta, T. Sakari Kuusela, Rutta Sarkkinen, Hannu Aittoniemi, Janne Vuorinen, Tytti Hakanen, Antti J Puolakkainen, Mirja Euro Surveill Rapid Communication Since February 2019, over 160 Chlamydia trachomatis (CT) cases testing negative or equivocal by Aptima Combo 2 (AC2) but positive by Aptima CT test run with Panther instruments occurred in Finland. The AC2 test targets chlamydial 23S rRNA while the CT test targets 16S rRNA. Sequencing of 10 strains revealed a nucleotide substitution in 23S rRNA. The significance of this for the failure of the AC2 test to detect the variant is not yet known. European Centre for Disease Prevention and Control (ECDC) 2019-05-30 /pmc/articles/PMC6549458/ /pubmed/31164192 http://dx.doi.org/10.2807/1560-7917.ES.2019.24.22.1900298 Text en This article is copyright of the authors or their affiliated institutions, 2019. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made. |
| spellingShingle | Rapid Communication Rantakokko-Jalava, Kaisu Hokynar, Kati Hieta, Niina Keskitalo, Anniina Jokela, Pia Muotiala, Anna Jokiranta, T. Sakari Kuusela, Rutta Sarkkinen, Hannu Aittoniemi, Janne Vuorinen, Tytti Hakanen, Antti J Puolakkainen, Mirja Chlamydia trachomatis samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019 |
| title |
Chlamydia trachomatis samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019 |
| title_full |
Chlamydia trachomatis samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019 |
| title_fullStr |
Chlamydia trachomatis samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019 |
| title_full_unstemmed |
Chlamydia trachomatis samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019 |
| title_short |
Chlamydia trachomatis samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019 |
| title_sort | chlamydia trachomatis samples testing falsely negative in the aptima combo 2 test in finland, 2019 |
| topic | Rapid Communication |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549458/ https://www.ncbi.nlm.nih.gov/pubmed/31164192 http://dx.doi.org/10.2807/1560-7917.ES.2019.24.22.1900298 |
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