Personalized prescription of imatinib in recurrent granulosa cell tumor of the ovary: case report

Ovarian cancer is the fifth leading cause of cancer-related female mortality and the most lethal gynecological cancer. In this report, we present a rare case of recurrent granulosa cell tumor (GCT) of the ovary. We describe the case of a 26-yr-old woman with progressive GCT of the right ovary despit...

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Detalles Bibliográficos
Autores principales: Poddubskaya, Elena V., Baranova, Madina P., Allina, Daria O., Sekacheva, Marina I., Makovskaia, Lyudmila A., Kamashev, Dmitriy E., Suntsova, Maria V., Barbara, Viktoria S., Kochergina-Nikitskaya, Irina N., Aleshin, Alexey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549576/
https://www.ncbi.nlm.nih.gov/pubmed/30655270
http://dx.doi.org/10.1101/mcs.a003434
Descripción
Sumario:Ovarian cancer is the fifth leading cause of cancer-related female mortality and the most lethal gynecological cancer. In this report, we present a rare case of recurrent granulosa cell tumor (GCT) of the ovary. We describe the case of a 26-yr-old woman with progressive GCT of the right ovary despite multiple lines of therapy who underwent salvage therapy selection based on a novel bioinformatical decision support tool (Oncobox). This analysis generated a list of potentially actionable compounds, which when used clinically lead to partial response and later long-term stabilization of the patient's disease.

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