Personalized prescription of imatinib in recurrent granulosa cell tumor of the ovary: case report

Ovarian cancer is the fifth leading cause of cancer-related female mortality and the most lethal gynecological cancer. In this report, we present a rare case of recurrent granulosa cell tumor (GCT) of the ovary. We describe the case of a 26-yr-old woman with progressive GCT of the right ovary despit...

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Autores principales: Poddubskaya, Elena V., Baranova, Madina P., Allina, Daria O., Sekacheva, Marina I., Makovskaia, Lyudmila A., Kamashev, Dmitriy E., Suntsova, Maria V., Barbara, Viktoria S., Kochergina-Nikitskaya, Irina N., Aleshin, Alexey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549576/
https://www.ncbi.nlm.nih.gov/pubmed/30655270
http://dx.doi.org/10.1101/mcs.a003434
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author Poddubskaya, Elena V.
Baranova, Madina P.
Allina, Daria O.
Sekacheva, Marina I.
Makovskaia, Lyudmila A.
Kamashev, Dmitriy E.
Suntsova, Maria V.
Barbara, Viktoria S.
Kochergina-Nikitskaya, Irina N.
Aleshin, Alexey A.
author_facet Poddubskaya, Elena V.
Baranova, Madina P.
Allina, Daria O.
Sekacheva, Marina I.
Makovskaia, Lyudmila A.
Kamashev, Dmitriy E.
Suntsova, Maria V.
Barbara, Viktoria S.
Kochergina-Nikitskaya, Irina N.
Aleshin, Alexey A.
author_sort Poddubskaya, Elena V.
collection PubMed
description Ovarian cancer is the fifth leading cause of cancer-related female mortality and the most lethal gynecological cancer. In this report, we present a rare case of recurrent granulosa cell tumor (GCT) of the ovary. We describe the case of a 26-yr-old woman with progressive GCT of the right ovary despite multiple lines of therapy who underwent salvage therapy selection based on a novel bioinformatical decision support tool (Oncobox). This analysis generated a list of potentially actionable compounds, which when used clinically lead to partial response and later long-term stabilization of the patient's disease.
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spelling pubmed-65495762019-06-19 Personalized prescription of imatinib in recurrent granulosa cell tumor of the ovary: case report Poddubskaya, Elena V. Baranova, Madina P. Allina, Daria O. Sekacheva, Marina I. Makovskaia, Lyudmila A. Kamashev, Dmitriy E. Suntsova, Maria V. Barbara, Viktoria S. Kochergina-Nikitskaya, Irina N. Aleshin, Alexey A. Cold Spring Harb Mol Case Stud Research Report Ovarian cancer is the fifth leading cause of cancer-related female mortality and the most lethal gynecological cancer. In this report, we present a rare case of recurrent granulosa cell tumor (GCT) of the ovary. We describe the case of a 26-yr-old woman with progressive GCT of the right ovary despite multiple lines of therapy who underwent salvage therapy selection based on a novel bioinformatical decision support tool (Oncobox). This analysis generated a list of potentially actionable compounds, which when used clinically lead to partial response and later long-term stabilization of the patient's disease. Cold Spring Harbor Laboratory Press 2019-04 /pmc/articles/PMC6549576/ /pubmed/30655270 http://dx.doi.org/10.1101/mcs.a003434 Text en © 2019 Poddubskaya et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted reuse and redistribution provided that the original author and source are credited.
spellingShingle Research Report
Poddubskaya, Elena V.
Baranova, Madina P.
Allina, Daria O.
Sekacheva, Marina I.
Makovskaia, Lyudmila A.
Kamashev, Dmitriy E.
Suntsova, Maria V.
Barbara, Viktoria S.
Kochergina-Nikitskaya, Irina N.
Aleshin, Alexey A.
Personalized prescription of imatinib in recurrent granulosa cell tumor of the ovary: case report
title Personalized prescription of imatinib in recurrent granulosa cell tumor of the ovary: case report
title_full Personalized prescription of imatinib in recurrent granulosa cell tumor of the ovary: case report
title_fullStr Personalized prescription of imatinib in recurrent granulosa cell tumor of the ovary: case report
title_full_unstemmed Personalized prescription of imatinib in recurrent granulosa cell tumor of the ovary: case report
title_short Personalized prescription of imatinib in recurrent granulosa cell tumor of the ovary: case report
title_sort personalized prescription of imatinib in recurrent granulosa cell tumor of the ovary: case report
topic Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549576/
https://www.ncbi.nlm.nih.gov/pubmed/30655270
http://dx.doi.org/10.1101/mcs.a003434
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