Response to olaparib in a PALB2 germline mutated prostate cancer and genetic events associated with resistance

Prostate cancers harboring DNA repair gene alterations are particularly sensitive to PARP inhibitor treatment. We report a case of an advanced prostate cancer patient profiled within the NCT-MASTER (Molecularly Aided Stratification for Tumor Eradication Research) precision oncology program using nex...

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Detalles Bibliográficos
Autores principales: Horak, Peter, Weischenfeldt, Joachim, von Amsberg, Gunhild, Beyer, Burkhard, Schütte, Andreas, Uhrig, Sebastian, Gieldon, Laura, Klink, Barbara, Feuerbach, Lars, Hübschmann, Daniel, Kreutzfeldt, Simon, Heining, Christoph, Maier, Sebastian, Hutter, Barbara, Penzel, Roland, Schlesner, Matthias, Eils, Roland, Sauter, Guido, Stenzinger, Albrecht, Brors, Benedikt, Schröck, Evelin, Glimm, Hanno, Fröhling, Stefan, Schlomm, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549578/
https://www.ncbi.nlm.nih.gov/pubmed/30833416
http://dx.doi.org/10.1101/mcs.a003657

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