Cargando…

DCZ0814 induces apoptosis and G0/G1 phase cell cycle arrest in myeloma by dual inhibition of mTORC1/2

Purpose: The present study investigates the effect of DCZ0814 in multiple myeloma (MM) cells, and determines the molecular mechanism of its antitumor activity against MM. Methods: The effects of DCZ0814 were evaluated in vitro using human MM cell lines (ARP1 and OCI-MY5) and in vivo in a murine xeno...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kong, Yuanyuan, Li, Bo, Chang, Shuaikang, Gao, Lu, Xu, Zhijian, He, Wan, Yang, Guang, Xie, Bingqian, Chen, Gege, Hu, Liangning, Lu, Kang, Wang, Yingcong, Wu, Xiaosong, Zhu, Weiliang, Shi, Jumei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549748/ https://www.ncbi.nlm.nih.gov/pubmed/31213901 http://dx.doi.org/10.2147/CMAR.S194202

Ejemplares similares

Preclinical activity of DCZ3301, a novel aryl-guanidino compound in the therapy of multiple myeloma
por: Gao, Minjie, et al.
Publicado: (2017)

A novel M phase blocker, DCZ3301 enhances the sensitivity of bortezomib in resistant multiple myeloma through DNA damage and mitotic catastrophe
por: Hu, Liangning, et al.
Publicado: (2020)

DCZ3301, a novel cytotoxic agent, inhibits proliferation in diffuse large B-cell lymphoma via the STAT3 pathway
por: Sun, Xi, et al.
Publicado: (2017)

The novel norcantharidin derivative DCZ5417 suppresses multiple myeloma progression by targeting the TRIP13–MAPK–YWHAE signaling pathway
por: Wang, Yingcong, et al.
Publicado: (2023)

A novel silicone derivative of natural osalmid (DCZ0858) induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma via the JAK2/STAT3 pathway
por: Lu, Kang, et al.
Publicado: (2020)

A novel alkaloid compound, DCZ0358, exerts significant antitumor activity in bortezomib-resistant multiple myeloma cells through inhibition of JAK2/STAT3 pathway: Anti-myeloma activity of a novel alkaloid in drug-resistant cells
por: Zhang, Bibo, et al.
Publicado: (2023)

Glycolysis is suppressed by DCZ0801-induced inactivation of the Akt/mTOR pathway in Multiple Myeloma
por: Feng, Qilin, et al.
Publicado: (2020)

Metformin induces autophagy and G0/G1 phase cell cycle arrest in myeloma by targeting the AMPK/mTORC1 and mTORC2 pathways
por: Wang, Yan, et al.
Publicado: (2018)

Pterostilbene Induces Cell Apoptosis and Cell Cycle Arrest in T-Cell Leukemia/Lymphoma by Suppressing the ERK1/2 Pathway
por: Chang, Gaomei, et al.
Publicado: (2017)

Ferroportin downregulation promotes cell proliferation by modulating the Nrf2–miR-17-5p axis in multiple myeloma
por: Kong, Yuanyuan, et al.
Publicado: (2019)

Pterostilbene Inhibits Human Multiple Myeloma Cells via ERK1/2 and JNK Pathway In Vitro and In Vivo
por: Xie, Bingqian, et al.
Publicado: (2016)

A novel phosphoramide compound, DCZ0805, shows potent anti-myeloma activity via the NF-κB pathway
por: Gao, Xuejie, et al.
Publicado: (2021)

TRIP13 impairs mitotic checkpoint surveillance and is associated with poor prognosis in multiple myeloma
por: Tao, Yi, et al.
Publicado: (2017)

Pterostilbene induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma cells
por: Kong, Yuanyuan, et al.
Publicado: (2016)

mTORC1 and mTORC2 in cancer and the tumor microenvironment
por: Kim, Laura C., et al.
Publicado: (2016)

DCZ19931, a novel multi-targeting kinase inhibitor, inhibits ocular neovascularization
por: Zhang, Huiying, et al.
Publicado: (2022)

mTORC1 controls the adaptive transition of quiescent stem cells from G(0) to G(Alert)
por: Rodgers, Joseph T., et al.
Publicado: (2014)

Gαq activation modulates autophagy by promoting mTORC1 signaling
por: Cabezudo, Sofía, et al.
Publicado: (2021)

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
por: Tang, Haiyang, et al.
Publicado: (2018)

Regulation of Autophagy through TORC1 and mTORC1
por: Noda, Takeshi
Publicado: (2017)

G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling
por: Prentzell, Mirja Tamara, et al.
Publicado: (2021)

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling
por: Merhi, Ahmad, et al.
Publicado: (2017)

Suppression of Pathological Ocular Neovascularization by a Small Molecular Multi-Targeting Kinase Inhibitor, DCZ19903
por: Ding, Jingjuan, et al.
Publicado: (2022)

Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication
por: Kuss-Duerkop, Sharon K., et al.
Publicado: (2017)

Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2
por: Luo, Yan, et al.
Publicado: (2015)

Preclinical validation and phase I trial of 4-hydroxysalicylanilide, targeting ribonucleotide reductase mediated dNTP synthesis in multiple myeloma
por: Xie, Yongsheng, et al.
Publicado: (2022)

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
por: Ding, Xiaolei, et al.
Publicado: (2016)

LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion
por: Ribeiro, Marcelle C., et al.
Publicado: (2018)

mTORC1 and mTORC2 differentially promote natural killer cell development
por: Yang, Chao, et al.
Publicado: (2018)

mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
por: Yang, Jin Young, et al.
Publicado: (2019)

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2
por: Kosillo, Polina, et al.
Publicado: (2022)

Glutaminolysis feeds mTORC1
por: Durán, Raúl V., et al.
Publicado: (2012)

Regulation of adiposity by mTORC1
por: Magdalon, Juliana, et al.
Publicado: (2017)

Uropathogenic Escherichia coli Infection Compromises the Blood-Testis Barrier by Disturbing mTORC1-mTORC2 Balance
por: Lu, Yongning, et al.
Publicado: (2021)

LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control
por: Gan, Wenjian, et al.
Publicado: (2020)

An mTORC1 to HRI signaling axis promotes cytotoxicity of proteasome inhibitors in multiple myeloma
por: Darawshi, Odai, et al.
Publicado: (2022)

mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors
por: Zhu, Ping Jun, et al.
Publicado: (2018)

An expanded role for mTORC1 in autophagy
por: Kim, Young-Mi, et al.
Publicado: (2015)

mTORC1 as the main gateway to autophagy
por: Rabanal-Ruiz, Yoana, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_kjeuabh4sn5pn9qj0qkhc47mt7