A dual-functional HER2 aptamer-conjugated, pH-activated mesoporous silica nanocarrier-based drug delivery system provides in vitro synergistic cytotoxicity in HER2-positive breast cancer cells

Purpose: As well as functioning as a ligand that is selectively internalized by cells overexpressing human epidermal growth factor receptor-2 (HER2), HApt can exert cytotoxic effects by inducing cross-linking and subsequent translocation of HER2 to cytoplasmic vesicles, such downregulation of HER2 i...

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Detalles Bibliográficos
Autores principales: Shen, Yinxing, Li, Mengya, Liu, Tianqi, Liu, Jing, Xie, Youhua, Zhang, Junqi, Xu, Shouhong, Liu, Honglai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549788/
https://www.ncbi.nlm.nih.gov/pubmed/31213813
http://dx.doi.org/10.2147/IJN.S201688

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