Enhancer of Polycomb and the Tip60 complex repress hematological tumor initiation by negatively regulating JAK/STAT pathway activity

Myeloproliferative neoplasms (MPNs) are clonal hematopoietic disorders that cause excessive production of myeloid cells. Most MPN patients have a point mutation in JAK2 (JAK2(V617F)), which encodes a dominant-active kinase that constitutively triggers JAK/STAT signaling. In Drosophila, this pathway...

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Detalles Bibliográficos
Autores principales: Bailetti, Alessandro A., Negrón-Piñeiro, Lenny J., Dhruva, Vishal, Harsh, Sneh, Lu, Sean, Bosula, Aisha, Bach, Erika A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550037/
https://www.ncbi.nlm.nih.gov/pubmed/31072879
http://dx.doi.org/10.1242/dmm.038679

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550037/
https://www.ncbi.nlm.nih.gov/pubmed/31072879
http://dx.doi.org/10.1242/dmm.038679

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