Inhibition of the IGF-1–PI3K–Akt–mTORC2 pathway in lipid rafts increases neuronal vulnerability in a genetic lysosomal glycosphingolipidosis

Glycosphingolipid (GSL) accumulation is implicated in the neuropathology of several lysosomal conditions, such as Krabbe disease, and may also contribute to neuronal and glial dysfunction in adult-onset conditions such as Parkinson's disease, Alzheimer's disease and multiple sclerosis. GSL...

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Detalles Bibliográficos
Autores principales: Sural-Fehr, Tuba, Singh, Harinder, Cantuti-Catelvetri, Ludovico, Zhu, Hongling, Marshall, Michael S., Rebiai, Rima, Jastrzebski, Martin J., Givogri, Maria I., Rasenick, Mark M., Bongarzone, Ernesto R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550048/
https://www.ncbi.nlm.nih.gov/pubmed/31036560
http://dx.doi.org/10.1242/dmm.036590

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550048/
https://www.ncbi.nlm.nih.gov/pubmed/31036560
http://dx.doi.org/10.1242/dmm.036590

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