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Dual effects of brain sparing opioid in newborn rats: Analgesia and hyperalgesia
Effective pain management in neonates without the unwanted central nervous system (CNS) side effects remains an unmet need. To circumvent these central effects we tested the peripherally acting (brain sparing) opioid agonist loperamide in neonate rats. Our results show that: 1) loperamide (1 mg/kg,...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550121/ https://www.ncbi.nlm.nih.gov/pubmed/31194154 http://dx.doi.org/10.1016/j.ynpai.2018.01.001 |