The GCN2 inhibitor IMPACT contributes to diet-induced obesity and body temperature control

IMPACT, a highly conserved protein, is an inhibitor of the eIF2α kinase GCN2. In mammals, it is preferentially expressed in neurons. Knock-down of IMPACT expression in neuronal cells increases basal GCN2 activation and eIF2α phosphorylation and decreases translation initiation. In the mouse brain, I...

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Detalles Bibliográficos
Autores principales: Pereira, Catia M., Filev, Renato, Dubiela, Francisco P., Brandão, Bruna B., Queiroz, Claudio M., Ludwig, Raissa G., Hipolide, Debora, Longo, Beatriz M., Mello, Luiz E., Mori, Marcelo A., Castilho, Beatriz A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550387/
https://www.ncbi.nlm.nih.gov/pubmed/31166980
http://dx.doi.org/10.1371/journal.pone.0217287

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