Exploring the relationship between the speed-resolved perfusion of blood flux and HRV following different thermal stimulations using MSE and MFE analyses

Our previous study employed the classic laser Doppler flux (LDF) to explore the complexity of local blood flow signals and their relationship with heart rate variability (HRV). However, microcirculation blood flow is composed of different velocity components. To investigate the complexity of local speed-resolved perfusion and HRV following stimulation with different temperatures in healthy subjects, multiscale entropy (MSE) and multiscale fuzzy entropy (MFE) were used to measure the complexity of local speed-resolved perfusion signals. MSE was also used to evaluate the complexity of HRV. The results indicated that thermal stimulation increased all components of local speed-resolved perfusion and that stimulation with different temperatures resulted in different changes in the complexity area index. However, the same stimulation had no effect on the MSE of HRV. Further research showed that 44°C thermal stimulation resulted in a weak correlation between the composite speed-resolved perfusion and the HRV complexity. The current study provides a new approach for studying the relationship between speed-resolved perfusion signals and cardiac function.