Large-scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine

OBJECTIVE: To identify a plasma metabolomic biomarker signature for migraine. METHODS: Plasma samples from 8 Dutch cohorts (n = 10,153: 2,800 migraine patients and 7,353 controls) were profiled on a (1)H-NMR-based metabolomics platform, to quantify 146 individual metabolites (e.g., lipids, fatty aci...

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Autores principales: Onderwater, Gerrit L.J., Ligthart, Lannie, Bot, Mariska, Demirkan, Ayse, Fu, Jingyuan, van der Kallen, Carla J.H., Vijfhuizen, Lisanne S., Pool, René, Liu, Jun, Vanmolkot, Floris H.M., Beekman, Marian, Wen, Ke-xin, Amin, Najaf, Thesing, Carisha S., Pijpers, Judith A., Kies, Dennis A., Zielman, Ronald, de Boer, Irene, van Greevenbroek, Marleen M.J., Arts, Ilja C.W., Milaneschi, Yuri, Schram, Miranda T., Dagnelie, Pieter C., Franke, Lude, Ikram, M. Arfan, Ferrari, Michel D., Goeman, Jelle J., Slagboom, P. Eline, Wijmenga, Cisca, Stehouwer, Coen D.A., Boomsma, Dorret I., van Duijn, Cornelia M., Penninx, Brenda W., 't Hoen, Peter A.C., Terwindt, Gisela M., van den Maagdenberg, Arn M.J.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550500/
https://www.ncbi.nlm.nih.gov/pubmed/30944236
http://dx.doi.org/10.1212/WNL.0000000000007313

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