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Galleria mellonella as a consolidated in vivo model hosts: New developments in antibacterial strategies and novel drug testing
A greater ethical conscience, new global rules and a modified perception of ethical consciousness entail a more rigorous control on utilizations of vertebrates for in vivo studies. To cope with this new scenario, numerous alternatives to rodents have been proposed. Among these, the greater wax moth...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550544/ https://www.ncbi.nlm.nih.gov/pubmed/31142220 http://dx.doi.org/10.1080/21505594.2019.1621649 |
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author | Cutuli, Marco Alfio Petronio Petronio, Giulio Vergalito, Franca Magnifico, Irene Pietrangelo, Laura Venditti, Noemi Di Marco, Roberto |
author_facet | Cutuli, Marco Alfio Petronio Petronio, Giulio Vergalito, Franca Magnifico, Irene Pietrangelo, Laura Venditti, Noemi Di Marco, Roberto |
author_sort | Cutuli, Marco Alfio |
collection | PubMed |
description | A greater ethical conscience, new global rules and a modified perception of ethical consciousness entail a more rigorous control on utilizations of vertebrates for in vivo studies. To cope with this new scenario, numerous alternatives to rodents have been proposed. Among these, the greater wax moth Galleria mellonella had a preponderant role, especially in the microbiological field, as demonstrated by the growing number of recent scientific publications. The reasons for its success must be sought in its peculiar characteristics such as the innate immune response mechanisms and the ability to grow at a temperature of 37°C. This review aims to describe the most relevant features of G. mellonella in microbiology, highlighting the most recent and relevant research on antibacterial strategies, novel drug tests and toxicological studies. Although solutions for some limitations are required, G. mellonella has all the necessary host features to be a consolidated in vivo model host. |
format | Online Article Text |
id | pubmed-6550544 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-65505442019-06-17 Galleria mellonella as a consolidated in vivo model hosts: New developments in antibacterial strategies and novel drug testing Cutuli, Marco Alfio Petronio Petronio, Giulio Vergalito, Franca Magnifico, Irene Pietrangelo, Laura Venditti, Noemi Di Marco, Roberto Virulence Review Article A greater ethical conscience, new global rules and a modified perception of ethical consciousness entail a more rigorous control on utilizations of vertebrates for in vivo studies. To cope with this new scenario, numerous alternatives to rodents have been proposed. Among these, the greater wax moth Galleria mellonella had a preponderant role, especially in the microbiological field, as demonstrated by the growing number of recent scientific publications. The reasons for its success must be sought in its peculiar characteristics such as the innate immune response mechanisms and the ability to grow at a temperature of 37°C. This review aims to describe the most relevant features of G. mellonella in microbiology, highlighting the most recent and relevant research on antibacterial strategies, novel drug tests and toxicological studies. Although solutions for some limitations are required, G. mellonella has all the necessary host features to be a consolidated in vivo model host. Taylor & Francis 2019-05-29 /pmc/articles/PMC6550544/ /pubmed/31142220 http://dx.doi.org/10.1080/21505594.2019.1621649 Text en © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Cutuli, Marco Alfio Petronio Petronio, Giulio Vergalito, Franca Magnifico, Irene Pietrangelo, Laura Venditti, Noemi Di Marco, Roberto Galleria mellonella as a consolidated in vivo model hosts: New developments in antibacterial strategies and novel drug testing |
title | Galleria mellonella as a consolidated in vivo model hosts: New developments in antibacterial strategies and novel drug testing |
title_full | Galleria mellonella as a consolidated in vivo model hosts: New developments in antibacterial strategies and novel drug testing |
title_fullStr | Galleria mellonella as a consolidated in vivo model hosts: New developments in antibacterial strategies and novel drug testing |
title_full_unstemmed | Galleria mellonella as a consolidated in vivo model hosts: New developments in antibacterial strategies and novel drug testing |
title_short | Galleria mellonella as a consolidated in vivo model hosts: New developments in antibacterial strategies and novel drug testing |
title_sort | galleria mellonella as a consolidated in vivo model hosts: new developments in antibacterial strategies and novel drug testing |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550544/ https://www.ncbi.nlm.nih.gov/pubmed/31142220 http://dx.doi.org/10.1080/21505594.2019.1621649 |
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