Cargando…

Galleria mellonella as a consolidated in vivo model hosts: New developments in antibacterial strategies and novel drug testing

A greater ethical conscience, new global rules and a modified perception of ethical consciousness entail a more rigorous control on utilizations of vertebrates for in vivo studies. To cope with this new scenario, numerous alternatives to rodents have been proposed. Among these, the greater wax moth...

Descripción completa

Detalles Bibliográficos
Autores principales: Cutuli, Marco Alfio, Petronio Petronio, Giulio, Vergalito, Franca, Magnifico, Irene, Pietrangelo, Laura, Venditti, Noemi, Di Marco, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550544/
https://www.ncbi.nlm.nih.gov/pubmed/31142220
http://dx.doi.org/10.1080/21505594.2019.1621649
_version_ 1783424203318362112
author Cutuli, Marco Alfio
Petronio Petronio, Giulio
Vergalito, Franca
Magnifico, Irene
Pietrangelo, Laura
Venditti, Noemi
Di Marco, Roberto
author_facet Cutuli, Marco Alfio
Petronio Petronio, Giulio
Vergalito, Franca
Magnifico, Irene
Pietrangelo, Laura
Venditti, Noemi
Di Marco, Roberto
author_sort Cutuli, Marco Alfio
collection PubMed
description A greater ethical conscience, new global rules and a modified perception of ethical consciousness entail a more rigorous control on utilizations of vertebrates for in vivo studies. To cope with this new scenario, numerous alternatives to rodents have been proposed. Among these, the greater wax moth Galleria mellonella had a preponderant role, especially in the microbiological field, as demonstrated by the growing number of recent scientific publications. The reasons for its success must be sought in its peculiar characteristics such as the innate immune response mechanisms and the ability to grow at a temperature of 37°C. This review aims to describe the most relevant features of G. mellonella in microbiology, highlighting the most recent and relevant research on antibacterial strategies, novel drug tests and toxicological studies. Although solutions for some limitations are required, G. mellonella has all the necessary host features to be a consolidated in vivo model host.
format Online
Article
Text
id pubmed-6550544
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-65505442019-06-17 Galleria mellonella as a consolidated in vivo model hosts: New developments in antibacterial strategies and novel drug testing Cutuli, Marco Alfio Petronio Petronio, Giulio Vergalito, Franca Magnifico, Irene Pietrangelo, Laura Venditti, Noemi Di Marco, Roberto Virulence Review Article A greater ethical conscience, new global rules and a modified perception of ethical consciousness entail a more rigorous control on utilizations of vertebrates for in vivo studies. To cope with this new scenario, numerous alternatives to rodents have been proposed. Among these, the greater wax moth Galleria mellonella had a preponderant role, especially in the microbiological field, as demonstrated by the growing number of recent scientific publications. The reasons for its success must be sought in its peculiar characteristics such as the innate immune response mechanisms and the ability to grow at a temperature of 37°C. This review aims to describe the most relevant features of G. mellonella in microbiology, highlighting the most recent and relevant research on antibacterial strategies, novel drug tests and toxicological studies. Although solutions for some limitations are required, G. mellonella has all the necessary host features to be a consolidated in vivo model host. Taylor & Francis 2019-05-29 /pmc/articles/PMC6550544/ /pubmed/31142220 http://dx.doi.org/10.1080/21505594.2019.1621649 Text en © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Cutuli, Marco Alfio
Petronio Petronio, Giulio
Vergalito, Franca
Magnifico, Irene
Pietrangelo, Laura
Venditti, Noemi
Di Marco, Roberto
Galleria mellonella as a consolidated in vivo model hosts: New developments in antibacterial strategies and novel drug testing
title Galleria mellonella as a consolidated in vivo model hosts: New developments in antibacterial strategies and novel drug testing
title_full Galleria mellonella as a consolidated in vivo model hosts: New developments in antibacterial strategies and novel drug testing
title_fullStr Galleria mellonella as a consolidated in vivo model hosts: New developments in antibacterial strategies and novel drug testing
title_full_unstemmed Galleria mellonella as a consolidated in vivo model hosts: New developments in antibacterial strategies and novel drug testing
title_short Galleria mellonella as a consolidated in vivo model hosts: New developments in antibacterial strategies and novel drug testing
title_sort galleria mellonella as a consolidated in vivo model hosts: new developments in antibacterial strategies and novel drug testing
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550544/
https://www.ncbi.nlm.nih.gov/pubmed/31142220
http://dx.doi.org/10.1080/21505594.2019.1621649
work_keys_str_mv AT cutulimarcoalfio galleriamellonellaasaconsolidatedinvivomodelhostsnewdevelopmentsinantibacterialstrategiesandnoveldrugtesting
AT petroniopetroniogiulio galleriamellonellaasaconsolidatedinvivomodelhostsnewdevelopmentsinantibacterialstrategiesandnoveldrugtesting
AT vergalitofranca galleriamellonellaasaconsolidatedinvivomodelhostsnewdevelopmentsinantibacterialstrategiesandnoveldrugtesting
AT magnificoirene galleriamellonellaasaconsolidatedinvivomodelhostsnewdevelopmentsinantibacterialstrategiesandnoveldrugtesting
AT pietrangelolaura galleriamellonellaasaconsolidatedinvivomodelhostsnewdevelopmentsinantibacterialstrategiesandnoveldrugtesting
AT vendittinoemi galleriamellonellaasaconsolidatedinvivomodelhostsnewdevelopmentsinantibacterialstrategiesandnoveldrugtesting
AT dimarcoroberto galleriamellonellaasaconsolidatedinvivomodelhostsnewdevelopmentsinantibacterialstrategiesandnoveldrugtesting